Talk:Reference genome

Untitled

Add table of human genome releases from here? https://genome.ucsc.edu/FAQ/FAQreleases.html#release1 Hdash (talk) 12:11, 30 July 2014 (UTC)

Have started this table. Jmc200 (talk) 14:01, 18 August 2016 (UTC)

I would like to know how the transition from NCBI to GRC happened, but I'm struggling to find any good sources on this. Jmc200 (talk) 12:54, 23 August 2016 (UTC)

Where is the claim about "GRCh38 in 2017.[15] This build only has 120 gaps" from? I could only find the reference about GRCh37 having 250 gaps.

Meanwhile, GRCh38.p14 is out, and the claim about GRCh39 indefinitely postponed is gone. — Preceding unsigned comment added by Mltam (talk • contribs) 23:15, 18 August 2022 (UTC)

Hi Mltam,

About the first claim "GRCh38 in 2017.[15] This build only has 120 gaps". After reading the reference more carefully, it looks like an misunderstanding. In the reference 15, the table 1, there's a comparison between GRCh37 and GRCh38 and that number doesn't appear at all, but in the reference [18], the table 1, which is a comparison GRCh38 vs T2T-CHM13v1.1, it does shows that GRCh38 has 120.31 gap Mbp (not 120 individual gaps). So, i'll try to fix it.

About GRCh39. Yes, it may be that there's no demand for its release now that GRCh38.p14 has been published, but currently GRCh39 is still expected to release in the near future. So, I think it is important to, at least, mention it. Aarón Mayo (talk) 10:43, 19 August 2022 (UTC)

Expansion of the article

Hi,

I've been adding content to the article, which, I believe, has greatly improved since its state in May (Reference genome - Wikipedia) and I just wanted to invite anyone interested to edit any new content if they consider it necessary and to expand the rest of the article. I see three topics with expansion potential: "Properties of reference genomes", where we could talk about contigs and scaffolds and how they are constructed, and gap types (scaffold nonbreaking gaps between contigs and scaffold breaking gaps); "Mouse reference genome", where the structure of the "human reference genome" section could be replicated, adding a little of history of its assemblies and patches; "Other genomes", where we could talk about some specific model organism and its reference genome.

Regarding, Aarón Mayo (talk) 08:08, 21 August 2022 (UTC)

Hello,

As a course assignment I am going to make some edits on this article. I had my master thesis (see here) on Reference Genome Impact on Population Genomic analyses so I think I have a couple of valuable things to add and mainly I will try to make the definition more broad and accurate. Eleftherios Darzentas (talk) 16:26, 8 November 2025 (UTC)

Welcome aboard, glad to have an expert working on the article! Citing (talk) 18:50, 10 November 2025 (UTC)