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Psilocybin is a former featured article. Please see the links under Article milestones below for its original nomination page (for older articles, check the nomination archive) and why it was removed.
This article appeared on Wikipedia's Main Page as Today's featured article on February 29, 2012.
This article is substantially duplicated in one or more external publications. Since these publication(s) copied Wikipedia, rather than the reverse, please do not flag this article as a copyright violation of the following source:
Pharmacology and Abuse of Cocaine, Amphetamines, Ecstasy and Related Designer Drugs, 2010
Additional comments
While researching sources for this article, I found the following text from the 2010 book "Pharmacology and Abuse of Cocaine, Amphetamines, Ecstasy and Related Designer Drugs" (Springer, isbn=978-90-481-2447-3), in the chapter "The Mushroom Psilocybin with Psychedelic Properties " by Enno Freye:
"The toxicity of psilocybin is relatively low; in rats, the oral LD50 is 280 mg/kg, approximately one and a half times that of caffeine. When administered intravenously in rabbits, psilocybin’s LD50 is approximately 12.5 mg/kg [138]. However, rabbits are extremely intolerant to the effects of most psychoactive drugs. The lethal dose from psilocybin intake alone is unknown at recreational or medicinal levels, and has never been documented; psilocybin makes up roughly 1% of the weight of Psilocybe cubensis mushrooms, and so nearly 1.7 kg of dried mushrooms, or 17 kg of fresh mushrooms, would be required for a 60 kg person to reach the 280 mg/kg LD50 rate of rats."
The wording is almost identical to the Wikipedia article. Worried that this was a copyvio, I checked the article history, and found that the Wikipedia text has been there since 2006—long before the publication of the book. I further checked their citation #138, Passie et al. (2002) "The pharmacology of psilocybin" Addiction Biology7:357-64 (PMID14578010). This source does support the LD50 of 280 mg/kg in rats, but does not mention one for rabbits. Note that the rest of the Freye paragraph is not cited. Thought I'd throw this out here in case in comes up in the future. Sasata (talk) 19:18, 2 March 2011 (UTC)Reply
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Latest comment: 2 years ago1 comment1 person in discussion
This article was the subject of a Wiki Education Foundation-supported course assignment, between 29 January 2024 and 23 February 2024. Further details are available on the course page. Student editor(s): ChasYoung4(article contribs).
Latest comment: 6 months ago1 comment1 person in discussion
I've noticed the 'Effects' section is very long while the 'Adverse Effects' section is very short (the caveat being 'Interactions' and similar making up more 'negative effect' length, but not being organized that way in technicality). Please analyze this and see if changing the organization can make the information look more neutral. ~2026-50158-7 (talk) 16:39, 23 January 2026 (UTC)Reply
level-5 vital article is rated B-class on Wikipedia's content assessment scale.
This article was the subject of a Wiki Education Foundation-supported course assignment, between 29 January 2024 and 23 February 2024. Further details are available on the course page. Student editor(s): ChasYoung4 (article contribs).