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This is the talk page for discussing improvements to the Methamphetamine article. This is not a forum for general discussion of the subject of the article.
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The text of the entry was: Did you know ...that Ice is a highly addictive methamphetamine and that when it is smoked it causes a massive release of dopamine in the brain?
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Latest comment: 1 year ago1 comment1 person in discussion
I swear to god people have told me it lasts about 6 hours and they used ammonia, not methylamine in the manufacturing of "meth". Amphetamine has been known to make people very violent, well, a specific population, people in Cluster B and C personality disorders. Actual methamphetamine has displayed increased cognition but heightened paranoia and shadow people despite being awake for only 18 hours. Methamphetamine activates sigma1-receptors which contributes to the stronger creativity aspect of it but that ends up blending into reality like 8 - 16 hours later. It has lasted 7 days after one dose in some people due to non-linear pharmacokinetics.
Meth should be "Methamphetamine Hydrochloride" not "Amphetamine Hydrobromide"
Latest comment: 3 months ago4 comments4 people in discussion
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Greetings and good day! I wanted to clarify an error made on this page that I feel is important due to it's medical inaccuracy. With regard to the statement in the first section 1st paragraph, perhaps the second, it states that on note 3 that Desoxyn medical information insert, that the active ingredient is dextroamphetamine, and also claims there to be some elaborate different chemical that claims to be proof it is dextroamphetamine. That...is 100% absolutely not true. Adderall is dextroamphetamine. Desoxyn is the prescription name brand of the drug Methamphetamine hcl. It comes in 5mg and 10mg tablets. 5mg and 10mg of dextroamphetamine are barely therapeutic doses for a 6 year old child, much less for anyone older than that. Desoxyn is prescribed for a variety of disorders, illnesses, or activities. This includes for ADHD, hypothyroidism that 1 results in uncontrollable weight gain, and 2 for lethargy for that and similar conditions, narcolepsy, obesity and weight loss, for patients suffering from low stamina for any number of reasons, major depressive disorder, and apparently minor and major traumatic brain injuries and others. Activities may prescribe Desoxyn including: Over night flights in fighter jets and bomber aircraft, long missions carried out by military soldiers, and other civilian activities that require focus, and alertness with a small margin for falling asleep or suffering from something similar to sentry fatigue.
I definitely am absolutely sure this to be true, and who or whomever edited this is playing with fire, it is never okay to lie or deceive others simply because you may disagree or dislike a drug or it's effects. Wikipedia is supposed to be based in fact, not someone's personal attempt to mislead people.
Please, change the article so that it is accurate before someone reads this for the sake of researching the drug and is provided with false information. This kind of thing has killed people, giving readers a false sense of security and potentially leading to overdose as like I stated 5mg of dextroamphetamine is not even a therapeutic dose, while 5mg of Methamphetamine to a person that has not taken it before is much different and much much stronger than dextroamphetamine. I definitely do not want that to ever happen so please change this.
Not done: I have reviewed the article, and your claims do not align with the current contents of the article. I believe that you are getting dextromethamphetamine confused with dextroamphetamine. The two are distinctly different chemical compounds. Desoxyn is declared as methamphetamine, but actually contains dextromethamphetamine. No other FDA approved drug contains dextromethamphetamine. The various amphetamine isomers used in other FDA approved amphetamine-based drugs are dextroamphetamine (Dexedrine, Zenzedi), the dextroamphetamine prodrug lisdexamfetamine (Vyvanse), mixtures of various different dextroamphetamine and levoamphetamine salts (Adderall, Adderall XR, Mydayis), or racemic amphetamine (Evekeo). Hope this helps clarify things for you. Garzfoth (talk) 22:14, 19 October 2025 (UTC)Reply
I was the editor responsible for that note and all the statements in the article that distinguish dextromethamphetamine from racemic methamphetamine in the context of methamphetamine hydrochloride in general. Garzfoth already mentioned that you are confusing dextroamphetamine with d-methamphetamine (likely because dexamphetamine is common vernacular among stakeholders [e.g., ADHD patients], whereas the latter isn't).
Re: "claims there to be some elaborate different chemical that claims to be proof it is dextroamphetamine. That...is 100% absolutely not true."
I actually wrote the note as an explanation for anyone who didn't wish to view any of the in-text citations, one of which states that "Desoxyn, which is d-meth" verbatim.[1] For context, here is the note that's based entirely on the Desoxyn package insert:
"The medication package insertfor Desoxyn lists the chemical name (S)-N,α-dimethylbenzeneethanamine hydrochloride, which explicitly identifies the compound as dextromethamphetamine (the S-enantiomer) with no stereochemicalambiguity."
Please visit Enantiomer#Naming_conventions to understand the significance of "(S)" (NB: you can also read this review[2]); It would be a massive scandal with non-trivial legal consequences if the manufacturer of Desoxyn applied for production permits and marketing approval for a controlled substance from the DEA and USFDA respectively, whilst producing an entirely different controlled substance in secret. The active ingredient listed on the package insert is correct.
Methamphetamine as the ADHD medication that is the exception to the enantiomer-inclusive non-proprietary name convention is again verified by this citation, which is cited in Methamphetamine#medical.[3] As for why methamphetamine hydrochloride is the non-proprietary name, my understanding is that medically prescribed formulations of meth have always included d-meth, whereas amphetamine was initially prescribed as the racemate under Benzedrine. I'm only guessing, but the decision to not manufacture pharmaceutical formulations of racemic methamphetamine hydrochloride may stem from the fact that there's even greater pharmacodynamic differences between d- and l-meth than the two amphetamine enantiomers - so much so that l-meth appears to be largely inactive in the central nervous system at therapeutic doses.[2] As an aside, Levomethamphetamine, when used as an OTC decongestant, is explicitly identified as "levmetamfetamine" on packaging and not "methamphetamine hydrochloride". Professional Crastination (talk) 04:29, 6 April 2026 (UTC)Reply
12Barkholtz HM, Hadzima R, Miles A (July 2023). "Pharmacology of R-(-)-Methamphetamine in Humans: A Systematic Review of the Literature". ACS Pharmacology & Translational Science. 6 (7): 914–924. doi:10.1021/acsptsci.3c00019. PMC10353062. PMID37470013. Methamphetamine exists as two stereoisomers: S-(+)-methamphetamine ((+)-MAMP) and R-(−)-methamphetamine ((−)-MAMP). The (+)-MAMP stereoisomer is a well-known central nervous system stimulant and drug of abuse,1 available in both pharmaceutical and clandestine preparations across the globe. However, the (−)-MAMP stereoisomer is less well understood, despite the long-term availability (prior to 1994)2−4 of the over-the-counter (OTC) nasal decongestant in the Vicks Vapor Inhaler (marketed by Procter & Gamble).... This dose range also lacked physiological activity as study drug administration did not result in relevant heart rate, blood pressure, core temperature, respiration rate, or oxygen saturation changes compared to the placebo, as detailed in Table 4. Furthermore, no differences were detected in participant-reported subjective effects of study drug administration compared to the placebo. From this work, we learn that orally administered doses of (−)-MAMP at or below 10 mg do not result in significant physiological or subjective effects.
Latest comment: 3 months ago2 comments2 people in discussion
A number of assertions in this article, namely regarding neurotoxicity as an inherent or unavoidable consequence of methamphetamine usage, and that "party and play" sex participants using the drug for that purpose are "mostly homosexual men". In my experience as to the latter claim, heterosexual and homosexual users are participants in the occasionally aphrodisiatic effects of the drug; that the average hetero also heavily relies on Internet dating and meetup apps to facilitate these activities, and do so even without methamphetamine being involved in the casual sex encounter process , at all, serve as 'anecdotal' evidence debunking the inflammatory and defamatory assertion regarding "homosexual men" as being the group "mostly" involved in these activities. Regarding the neurotoxicity claims, it has been sufficiently demonstrated in controlled medical and scientific settings that vitamin d protects against the occasional neurotoxicity present with chronic or heavy usage of the drug. That even a single and readily available element that is synthesized by the human body even without artificial supplementation exists, should serve as an indicator that the sweeping claims of unavoidable or inherent neurotoxicity caused by methamphetamine consumption, are dubious at best, and more than likely 'defamatory' as far as the reputation of the drug is concerned. Gehstapohfagitz (talk) 16:47, 15 April 2026 (UTC)Reply
level-5 vital article is rated GA-class on Wikipedia's content assessment scale.
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Not done: it's not clear what changes you want to be made. Please mention the specific changes in a "change X to Y" format and provide a reliable source if appropriate. Sophisticatedevening (talk) 14:57, 26 February 2025 (UTC)
Not done: please provide reliable sources that support the change you want to be made. Bowler the Carmine | talk 05:22, 18 October 2025 (UTC)
Done - thanks for pointing that out - Arjayay (talk) 20:42, 29 October 2025 (UTC)