Talk:Maltol
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It should be noted that maltol may not be a benign food additive.
Harold D. Foster, PhD, notes research that suggests that maltol, especially as an aluminum-maltolate complex, damages the blood-brain barrier and so increases the ease with which aluminum, mercury and other toxins reach the brain. Aluminum neurotoxicity has been implicated, somewhat controversially, in the genesis of Alzheimer's desease.
As Dr. Foster summarizes in his book What Really Causes Alzheimer's Disease, "The ability of aluminum to cross the blood-brain barrier is strongly influenced by the form in which it is absorbed and the levels of other compounds in the blood. Aluminum maltolate is particularly dangerous. On reaching the brain, aluminum interferes with those enzyme cofactors with which it is most antagonistic. These include calcium, magnesium, and probably zinc and phosphorous."
References:
Savory, J., Huang, Y., Herman, M.M. Reyes, M.R., Wills, M.R. Tau immunoreactivity associated with aluminum maltolate-induced neurofibrillary degeneration in rabbits. Brain Res., 1995, 669: 325-329.
Bergholf, R.L., Herman, M.M., Savory, J., Carpenter, R.M., Sturgill, B.C., Katsetos, C.D., VandenBerg, S.R., Wills, M.R. A long-term intravenous model of aluminum maltol toxicity in rabbits: tissue distribution, hepatic, renal, and neuronal cytoskeletal changes associated with systemic exposure. Toxicol. Appl. Pharmacol., 1989, 98: 58-74.
Kaneko N, Takada J, Yasui H, Sakurai H. Memory Deficit in Mice Administered Aluminum-maltolate Complex. Biometals. 2006 Feb;19(1):83-9.
Kaneko N, Yasui H, Takada J, Suzuki K, Sakurai H. Orally administrated aluminum-maltolate complex enhances oxidative stress in the organs of mice. J Inorg Biochem. 2004 Dec;98(12):2022-31.
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