Talk:Insulin

Wiki Education Foundation-supported course assignment

This article is or was the subject of a Wiki Education Foundation-supported course assignment. Further details are available on the course page. Student editor(s): Carmenmilagros.

Above undated message substituted from Template:Dashboard.wikiedu.org assignment by PrimeBOT (talk) 00:35, 17 January 2022 (UTC)

Merge articles

This article should be merged with the other language articles. There are two different Q wikipedia items Check these ones: https://es.wikipedia.org/wiki/Insulina https://en.wikipedia.org/wiki/Insulin You can't go through them through the Languages tabs! — Preceding unsigned comment added by Adam080 (talk • contribs) 23:16, 8 February 2020 (UTC)

metabolism of carbs and "fats"?

"It regulates the metabolism of carbohydrates and fats by promoting the absorption of glucose from the blood to skeletal muscles and fat tissue and by causing fat to be stored rather than used for energy." 

Insulin regulates the metabolism of fat? And carbohydrates? OK, i'm no scientist. But i thought insulin regulated the distribution of glucose. Could someone please take a look at this and verify or correct. ThankeeLonginus876 (talk) 14:47, 2 July 2015 (UTC)

Numerical error in Insulin article.

In the fourth paragraph of the article, it is stated that insulin is a protein of 110 amino acid residues, with a molecular mass of 5808 Da. It is preproinsulin that has a polypeptide length of 110 residues, and a molecular mass closer to 12,500 Da. After proteolytic processing prior to secretion, the active hormone insulin is composed of 51 residues in two chains crosslinked by cystine residues. The isotope-average molecular mass of the 51-residue insulin monomer is very close to 5808. 128.2.226.68 (talk) 15:42, 28 January 2016 (UTC)

CAN WE TALK INSULINE AS A ALCOHOL — Preceding unsigned comment added by 27.131.14.26 (talk) 08:07, 31 July 2016 (UTC)

Errors in discussion on Type 1 and 2 diabetes

Was briefly reading through the article when I located what I believe to be erroneous statements:

When the pancreatic beta cells are destroyed by an autoimmune process, insulin can no longer be synthesized or be secreted into the blood. This results in type 2 diabetes mellitus...

In type 1 diabetes mellitus the destruction of beta cells is less pronounced than in type 2 diabetes, and probably not due to an autoimmune process.

These statements are mixed up for Type 1 and 2 diabetes as far as I understand. There may be even more errors, a full review of the Insulin article by subject matter expert is highly recommended.

FinalStage (talk) 16:25, 29 August 2016 (UTC)

• This error seems to have been fixed now as I just looked at the article on October 25 2018. Vorbee (talk) 15:50, 25 October 2018 (UTC)

Intranasal insulin should get its own header/section I believe

I believe a new header should be added titled "Intranasal Insulin" as Intranasal Insulin has differing effects as traditional routes of administration for insulin.

It is important for people to know how Intranasal Insulin differs from subcutaneous injections. For example Intranasal Insulin has been researched to not cause hypoglycemia (source: https://www.ncbi.nlm.nih.gov/pubmed/23107220) and does not affect systemic glucose control (source: https://www.ncbi.nlm.nih.gov/pubmed/24101698). --CuriousGeorge16 (talk) 02:46, 23 January 2017 (UTC)

Question: Since this article has been critiqued as too long and unfocused does anyone agree that Intranasal Insulin should be briefly discussed here and linked to a new wikipedia article titled "Intranasal Insulin"? link to credible research studies on Intranasal Insulin here — Preceding unsigned comment added by CuriousGeorge16 (talk • contribs) 02:51, 23 January 2017 (UTC)

Expand on Inhaled Insulin?

There was only one mention of inhaled Insulin on this page. Do you guys think it would be beneficial to add that inhaled insulin has been linked to cancer or has at least been shown to be dangerous? (source here

Also I think we should distinguish between Inhaled Insulin and Intranasal Insulin as they seem similar to the layman but have vastly different effects and safety profiles. --CuriousGeorge16 (talk) 02:56, 23 January 2017 (UTC)

Regulation of the insulin gene

There is material at Draft:Regulation of the insulin gene which could possibly be used to expand the "Regulation" section or be made into a stand-alone article: Noyster (talk), 09:12, 18 November 2017 (UTC)

Economics of insulin

Clearly insulin is a necessary good for those who need it so ordinary price elasticity does not apply. However, the availability of competing brands and formulations mean that substitute goods should provide some elasticity. Does anyone have a marketplace explanation for the high price of insulin in today's marketplace in the USA? EdEveridge (talk) 19:18, 4 April 2019 (UTC)

This was linked from Hacker News:

HN thread:

173.228.123.207 (talk) 03:23, 26 June 2019 (UTC)

Source help needed

I'm sure you are correct in saying "The crystal structure of insulin in the solid state was determined by Dorothy Hodgkin in 1969". I'm just not seeing the source. Macdonald-ross (talk) 08:26, 4 May 2022 (UTC)

A sentence on Khadria, et al.

Using insulin lispro, in 2022, after 100 years since insulin was discovered, collaborative research between California Institute of Technology and Eli Lilly and Company first reported the diffusion of insulin in a live animal.

Hi all, I see a bit of back and forth between an IP, Loriendrew, Whywhenwhohow, and Ushistorygeek on whether to include a sentence (above) highlighting this paper in Molecular Metabolism in the article. My opinion is that we should not. Relevant policies are WP:NOTNEWS, which says "Wikipedia is not written in news style," and "breaking news should not be emphasized or treated differently from other information"; and WP:DUE which guides us to "represent all significant viewpoints... in proportion to the prominence of each viewpoint in the published reliable sources." If this paper starts getting mentioned in reviews on insulin (or the history of work on insulin) we'll mention it here. Until then, I think it's premature. I figured instead of reverting the addition again, I'd open a thread here for folks to share their thoughts. Ajpolino (talk) 16:13, 31 July 2022 (UTC)

My revert was not based on MEDRS, it was one of a single editor mass–adding different cites with a common author. To me that fell into a potential self–promotion or at least a COI. As with anything, a knowledgeable reviewer could reinclude them as warranted. Based on above, it does not look ready for inclusion.--☾Loriendrew☽ ☏(ring-ring) 17:25, 31 July 2022 (UTC)

I appreciate the guidance and discussion and agree with the consensus. Thanks @Ajpolino& @Loriendrew Ushistorygeek (talk) 19:40, 1 August 2022 (UTC)

References

Medical Uses: Ad?

The paragraph is written like an ad, by over emphasizing the features and seems out of place in the section.

The Dispovan Single-Use Pen Needle by HMD is India’s first insulin pen needle that makes self-administration easy. Featuring extra-thin walls and a multi-bevel tapered point, these pen needles prioritise patient comfort by minimising pain and ensuring seamless medication delivery. The product aims to provide affordable Pen Needles to the developing part of the country through its wide distribution channel. Additionally, the universal design of these needles guarantees compatibility with all insulin pens. 107.0.117.66 (talk) 19:44, 20 November 2023 (UTC)

Sounds like they just copied a description of it from the marketing website for the product. Definitely biased, that's for sure. VoidHalo (talk) 14:09, 4 July 2024 (UTC)

Relationship with Collip in 1921/1922

here is a secondary source: https://www.sciencehistory.org/education/scientific-biographies/frederick-banting-charles-best-james-collip-and-john-macleod/ Kmwittko (talk) 16:25, 20 August 2024 (UTC)

Fork off history section?

I wonder if a "History of insulin" article of its own would be better than having a long history section in an already fairly long article. Crystalespeon (talk) 18:26, 22 April 2026 (UTC)

Insulin Degradation through Protein-disulfide reductase

From current article: ”It is broken down by the enzyme, protein-disulfide reductase (glutathione), which breaks the disulphide bonds between the A and B chains…Degradation normally involves endocytosis of the insulin-receptor complex, followed by the action of insulin-degrading enzyme.”

I’ve been trying to track down the relationship of protein-disulfide reductase (glutathione) and insulin, and it has been a bit of a mess. Brenda lists two genes for enzymes of this class (https://www.brenda-enzymes.org/enzyme.php?ecno=1.8.4.2), DNAJC10 and TXNDC12, but neither have a gene card that even mentions insulin. DNAJC10 is in 1.8.4.-, and I think it’s not glutathione dependent, so I think it’s not actually in this class. TXNDC12 seems to create cysteine disulfide bonds, rather than destroy them.

The article cites the EC number description, but the claims about insulin degradation seem to be based on two really old papers (from 1963 and 1974), where they called it Glutathione-Insulin Transhydrogenase. From what I can gather from like (https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0018138) is that there was a lot of confusion back then, and the insulin degrading enzyme was actually a protein disulfide isomerase (PDI). That study also claims that the current consensus is that PDI breaks the disulfide bond after Insulin is degraded by IDE. With some more digging, it seems like it’s PDI1A1=P4HB specifically that’s annotated as being involved with insulin processing, and whose akas include Glutathione-Insulin Transhydrogenase Pabnau (talk) 23:50, 22 May 2026 (UTC)