Talk:Hypervariable region

Untitled

hypervariable regions only account for the non coding tandem repeat sequences of mtDNA, and thus are not found in chromosomes or normal human DNA.

Proposed merger with Complementarity determining region

I oppose the merger. The type of hypervariable region described in this article is housed within mitochondrial DNA and is different to the hypervariable region/complementarity determining region of antigen receptors like immunoglobulins and T-cell receptors. I found a review article that mentions this kind... (Falchi A, Giovannoni L, Calo C, Piras I, Moral P, Paoli G, Vona G, Varesi L (2006). "Genetic history of some western Mediterranean human isolates through mtDNA HVR1 polymorphisms". J. Hum. Genet. 51 (1): 9–14. PMID 16307178.{{cite journal}}: CS1 maint: multiple names: authors list (link))...but noticed there are also articles that describe hypervariable regions of viruses like hepatitis C virus (Smith D (1999). "Evolution of the hypervariable region of hepatitis C virus". J. Viral Hepat. 6 Suppl 1: 41–6. PMID 10760034.) so maybe a disambiguation page could be made that links to the three different types of HVR?? Best wishes Ciar 04:07, 27 April 2007 (UTC)

Split

I'm suggesting splitting this into two articles, one concerning nucleic acids (which most of this one is about) and one about antibodies, which could go into more details about the function (multiple sources mention antibodies). Alternatively, the article can be rewritten to include both, but the intro sentence needs to be more general. KingisNitro (talk) 15:03, 15 June 2022 (UTC)