Talk:Haloperidol

Most commonly used typical antipsychotic

The statement that "it is the most commonly used typical antipsychotic" would seem to be important enough that it should appear in the lede rather than at the end of the third paragraph, so I have moved it up. Piperh (talk) 08:39, 12 December 2015 (UTC)

Assessment comment

The comment(s) below were originally left at Talk:Haloperidol/CommentsTalk:Haloperidol/Comments, and are posted here for posterity. Following several discussions in past years, these subpages are now deprecated. The comments may be irrelevant or outdated; if so, please feel free to remove this section.

I rate this article a 6/10. It has too many headings and is not well organized. Its content is good, but the structure needs work.

Last edited at 17:07, 23 February 2007 (UTC). Substituted at 17:02, 29 April 2016 (UTC)

Neurotoxicity

User:Doc James: A while back I added this study to both the lede and the body of the article with the claim "haloperidol is neurotoxic". You removed the claim from the lede and changed the claim in the body to "haloperidol may be neurotoxic". The article finds finds clear evidence of neurotoxicity. The statement "further research is needed to confirm these findings" should not be taken as an indicator that the evidence is equivocal, as such statements are made indiscriminately in scientific literature and are uncorrellated with strength evidence. And even if the evidence were equivocal-- My god! Is this not worthy of the lede? -Wikiman2718 (talk) 08:57, 9 October 2019 (UTC)

Source says "A review of the literature suggests that haloperidol exerts measurable neurotoxic effects at all doses via many molecular mechanisms that lead to neuronal death." That means may, not definite... Doc James (talk · contribs · email) 09:12, 9 October 2019 (UTC)

@Doc James: The abstract is downplaying the risk. The article makes it clear that holoperidol and other first generation antipsychotics are neurotoxic. If you can't read the article, one of the authors wrote this editorial in which they make their views quite clear. And again, this is huge. Why did you take it out of the lede? This study found that IV haloperidol administration measurably decreases brain volume within two hours of administration. The authors commented that the brain returns to normal size soon after and concluded that haloperidol does not kill brain cells. However, studies on prolonged antipsychotic use (like the one in discussion) do find permanent decrease in brain volume, sometimes by up to ten percent. They forcibly inject kids with these drugs at the border, by the way. --Wikiman2718 (talk) 09:30, 9 October 2019 (UTC)

Because one study isn't enough to say anything for certain. Broad expert consensus may be stated with more certain terms, but for now 'suggests' would likely be more appropriate, without a place in the lede.

Asserting that the abstract is "downplaying the risk" without further qualification suggests that the article's new paragraph on neurotoxicity has been shaped by your primary personal opinion, which isn't what Wikipedia is for.

I'd agree with @Doc James on this. The additional information on neurotoxicity is interesting, but is certainly not a proportionate representation of the body of literature on this topic to date. AlexVojProc (talk) 01:17, 24 May 2023 (UTC)

References

Ventricular Tachycardia Risk Understated

Why do people get drugged with >20mg of this a day especially with Parkinson's Disease, this chemical was invented for Tourettes Syndrome and it was noted every single analog not displaying antipsychotic activity in rats and this indicates the expression of mutated Dopamine D2 receptors. It has been weaponized unfortunately and the inventor of this chemical never wanted it on the market for this reason. Neuroleptic Malignant Syndrome was discovered first via Haloperidol studies. Schizophrenia is an underactivation of Dopamine D1R in the dopaminergic mesocortical pathway and Overactivation of Dopamine D2R in the dopaminergic mesolimbic pathway. It reduces their motivation to carry out ADLs via Blockade of Dopamine D1 receptors and via CYP3A4 produces HPP+ which ultimately destroys dopaminergic neurons irreverisibly if taken chronically and worsens negative symptoms of schizophrenia. This chemical is why Schizophrenics score lower on IQ tests, they state "I'll get every answer wrong on purpose if you continue to give me Haldol". Also, it does prolong QTc intervals and increases body temperature leading to hyperthermia in institutions poorly ventilated and Ventricular Tachycardia can cause unexplained sudden death observed via hERG inhibition.

0-_)(*)(*)*)(*)((*)*)(&)*(&(*& 159.123.253.1 (talk) 15:40, 6 July 2025 (UTC)