Talk:Hachimoji DNA

Created talk-page

Created talk-page for the "Hachimoji DNA" article - Enjoy! :) Drbogdan (talk) 23:06, 21 February 2019 (UTC)

Comments

Nice. Now you need to describe the 8 bases and how they pair. Rowan Forest (talk) 23:57, 21 February 2019 (UTC)

Top key desired features of unnatural base pairs are 1) their ability to undergo replication without mutations; 2) transcription (into mRNA); 3) translation (into peptides/protein). Have any of these been attempted in vitro? In vivo? Rowan Forest (talk) 01:07, 22 February 2019 (UTC)

Some points I corrected: 1) catalytic RNA was transcribed, but no protein was translated from it. 2) Romesberg at the Scripps institute knows Benner from the past, but they do not work in the same team, therefore, Romesberg's company and its proteins are unrelated to hachomoji DNA. 3) Romesberg has produced proteins using his 6-base DNA, but Benner's hachimoji has not yet had mRNA transcribed nor translated into protein. Rowan Forest (talk) 20:11, 25 February 2019 (UTC)

Hi, I am curious as their doesn't seem to be a linked source: what kind of catalytic RNA has been made with Hachimojis? All I was able to find was that this possibility was theorised but never actually developped. Could this be reffering the article where they inserted Hachimoji base pairs into the spinach aptamer? Baptiste Rochette (talk) 11:44, 17 July 2025 (UTC)

Naming

What process came up with this name? Did they consider others and choose this as best of the lot? Hyperbolick (talk) 07:10, 22 February 2019 (UTC)

Names of new bases.

I found them in ChemSpider. --Sharouser (talk) —Preceding undated comment added 13:11, 22 February 2019 (UTC)

"ITN discussion"

IF Interested, the "Hachimoji DNA" article has been considered, and posted, in "In The News" (ITN]) - the related discussion is at => "Wikipedia:In the news/Candidates#(Posted) Four new letters in DNA alphabet" - (also, if interested, related news has been posted to "my FaceBook page") - in any case - Enjoy! :) Drbogdan (talk) 18:16, 23 February 2019 (UTC) - [updated - Drbogdan (talk) 15:32, 24 February 2019 (UTC)]

Article title of hachimoji DNA base P

I made a section at Wikipedia talk:WikiProject Chemistry#Article title of hachimoji DNA base P --Sharouser (talk) 15:08, 24 February 2019 (UTC)

In my view, the most appropriate article title is 5-Aza-7-deazaguanine. It does not contain any brackets. It avoids Wikipedia:Naming conventions (technical restrictions) --Sharouser (talk) 15:09, 24 February 2019 (UTC)

Usage of Hachimoji DNA

Its unclear how hachimoji DNA can help "develop clean diagnostics for human diseases, in DNA digital data storage, DNA barcoding, self-assembling nanostructures, and to make proteins with extra amino acids as well as novel drugs..." Sbbarker19 (talk) 16:28, 26 February 2019 (UTC)

Earlier DNA system by Benner

I just came across the article Artificially Expanded Genetic Information System and I noticed this was an earlier project by Dr. Benner. I did not read the references, but my thought is that you may want to merge that article into hachimoji article -as background history of its development. Cheers, Rowan Forest (talk) 01:10, 27 February 2019 (UTC)