Talk:Gastrin
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Sourcing and expansion
[edit]PMID 10381581 may well be what we are looking for. JFW | T@lk 06:07, 19 June 2008 (UTC)
ERROR? The article states that gastrin: "Impacts lower esophageal sphincter (LES) tone, causing it to relax.[7] Taking this into consideration, high levels of gastrin may play a role in the development of some of the more common LES disorders such as acid reflux disease."
I haven't been able to access [7], but this reference: Gastrin and Lower Esophageal Sphincter Tone http://archinte.ama-assn.org/cgi/content/summary/138/2/196 states: The gastrointestinal polypeptide gastrin, found in great abundance in the gastric antrium, was shown in 1970 to have a very dramatic effect in stimulating the smooth muscle segment of the lower esophageal sphincter (LES), and in causing marked increases in pressure in this region.
So shouldn't "relax" read the opposite, "contract"? And isn't it LOW levels of gastrin that might aggravate acid reflux disease? —Preceding unsigned comment added by Hughesr (talk • contribs) 14:38, 27 September 2010 (UTC)
Another one
[edit]Gastrin in GI diseases. Reading. doi:10.1053/j.gastro.2011.07.006 JFW | T@lk 20:14, 19 September 2011 (UTC)
- doi:10.1016/j.canlet.2005.06.025 - gastrin and cancer. JFW | T@lk 20:34, 19 September 2011 (UTC)
ERROR in Function?
[edit]The Article states among the functions that "[gastrin] Plays a role in the relaxation of the ileocecal valve.[7]". However in reference #7 the relaxation of the ileocecal valve is attributed to the direct effect of gastrin-releasing peptide (GRP) instead of gastrin itself. — Preceding unsigned comment added by 193.6.168.249 (talk) 07:42, 2 December 2016 (UTC)