Talk:GDF15
Add topicLatest comment: 2 years ago by 24.19.10.249 in topic Hyperemesis Gravidarum
 | This article is rated Start-class on Wikipedia's content assessment scale. It is of interest to the following WikiProjects: | |||||||||||||
| ||||||||||||||
Hyperemesis Gravidarum
[edit]https://doi.org/10.1038/s41586-023-06921-9 24.19.10.249 (talk) 02:35, 17 December 2023 (UTC)
overexpression of GDF-15 at mice heightens longevity 22-44%
[edit]Nonsentient AI Grok notes, "Effects in Mammals (Primarily Mice)
Overexpression/Transgenic Models: Transgenic mice overexpressing human GDF-15 (hNAG-1/hGDF15) show increased lifespan, improved metabolic health, reduced inflammation, resistance to diet-induced obesity, and fewer age-related pathologies (e.g., tumors, lesions). In female mice (two transgenic lines): On low-fat diet (LFD): Median lifespan extension of ~13–19% (12.8–19.5% increase, or 13–18.8 weeks longer). On high-fat diet (HFD): Median lifespan extension of ~24–44% (stronger effect, as HFD shortens WT lifespan more)."