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Latest comment: 8 months ago6 comments2 people in discussion
Almost all of this section is cited repeatedly from two publications that are clearly biased in one direction (hence their titles), "The Great American Hustle", and "The Great American Medicine Show". The story of Dr Shute has been recounted in less pointed locations, and some of the facts cited can even be sourced from Dr Shute's own books (he records his own criticism and ill-reception). (And this would be better.) As it is, the article looks lopsided, even if it is accurate. Drsruli (talk) 07:34, 22 January 2026 (UTC)Reply
It wasn't too difficult to websearch and find that actually Shute's claims have received some validation, and numerous studies and articles posted in medical journals do attest to a use for Vitamin E in treating various forms and symptoms of CVD, most notably angina. Many of these limit to categories of CVD that were not possible to distinguish in Shute's day. And many of the papers go so far as to mention Shute's work (thus invalidating many absolute statements in this wikipedia article). (Of course there are at least as many articles to be found which still repudiate Vitamin E therapeutically, and the matter remains controversial.) (In veterinary medicine, Vitamin E is still used and has been for decades.) Drsruli (talk) 07:51, 22 January 2026 (UTC)Reply
There is no clinical evidence to support his findings. Shute was not recommending a normal vitamin E range of supplementation, his recommendations were megadoses (see Orthomolecular medicine) which is firmly rejected by the scientific community as quackery and unsafe. Veg Historian (talk) 17:43, 22 January 2026 (UTC)Reply
It is incorrect to say that there is no clinical evidence to support (some of) his findings. To be clear, I am referring to therapeutic use of Vitamin E, using amounts impossible to obtain from diet. There is now some clinical evidence to support his findings. The two books from which most of the article and criticism is drawn are thirty and forty years old. Neither one is a scientific publication; both are popularizations. There are scientific journal publications (clinical studies) that support some of the claims that they dispute. Drsruli (talk) 08:08, 28 January 2026 (UTC)Reply
Are you asserting that large amounts of any vitamin used therapeutically is quackery and unsafe? (This is also incorrect, and some recognized therapies employ vitamins as drugs, beyond correcting nutritional deficiencies.) Drsruli (talk) 08:10, 28 January 2026 (UTC)Reply
(I don't know if you would prefer primary sources or secondary sources; the article only uses secondary sources, although it is customary to permit primary sources for science topics. See https://timesmachine.nytimes.com/timesmachine/1993/05/26/744693.html?pageNumber=53 TNYT article referencing two (then) recently published clinical studies "supporting Shutes' work". A similar article was published at around the same time in the LA Times. I can provide additional such, and also primary source journal publications also referencing Shute's work in supportive studies, but it only takes one exception to refute an absolute statement.) Drsruli (talk) 09:10, 28 January 2026 (UTC)Reply
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