Talk:Desflurane

Pharmacology

Articles indicate that desflurane undergoes negligible metabolism, which is perhaps more correct than stating that this drug is not metabolized. This is of particular importance when considering hepatotoxicity. Njoku D et.al. state that desflurane undergoes biotransformation when exposed to hepatic cytochrome P450, rendering metabolites that can trigger immunologic hepatitis in patients; such a case is described by Berghaus et.al. Baitisj (talk) 02:13, 23 August 2015 (UTC)

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Wiki Education assignment: Molecular Neuropharmacology

This article was the subject of a Wiki Education Foundation-supported course assignment, between 25 August 2025 and 8 December 2025. Further details are available on the course page. Student editor(s): Lboles1 (article contribs).

— Assignment last updated by Ms. Apple (talk) 23:22, 17 September 2025 (UTC)

Sorry only just noticed your assignment - if you have thoughts on the changes I made to the GHG section please let me know as I have no medical knowledge Chidgk1 (talk) 13:42, 28 September 2025 (UTC)

Info based on 2012 cite

I am not an expert but moved below here as not sure still correct or relevant as based on 2012 cite:

In addition to global warming potentials, drug potency and fresh gas flow rates must be considered for meaningful comparisons between anesthetic gases. When a steady state hourly amount of anesthetic necessary for 1 minimum alveolar concentration (MAC) at 2 liters per minute (LPM) for Sevoflurane, and 1 LPM for Desflurane and Isoflurane is weighted by the GWP, the clinically relevant quantities of each anesthetic can then be compared. On a per-MAC-hour basis, the total life cycle GHG impact of desflurane is more than 20 times higher than Isoflurane and Sevoflurane (1 minimal alveolar concentration-hour). Chidgk1 (talk) 13:39, 28 September 2025 (UTC)