Talk:Chlorphenamine
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Anticholinergic?
[edit]Most first generation antihistamines have some level or another of anticholinergic action, and by viewing the similar chemical structure of this drug to diphenhydramine (Benadryl), which is a potent anticholinergic, I would assume that chlorpheniramine has considerable anticholinergic action as well. Is this known to be true? If it is it should be included in the article.--206.28.43.6 (talk) 20:43, 16 August 2008 (UTC)
Yes, I agree. The apparent anticholinergic action has been reported many times for these antihistamines, additionally they sometimes have very pronounced impacts on the prostate gland in males. Perhaps as a direct result? Many men have arrived in emergency departments with prostate pain and inability to void urine after taking these medications as OTC cold symptom relievers. In some cases psuedoephedrine has also appeared to be the culprit. The article on acetylcholine doesn't mention many of the empirically known anticholinergics that are in common use as pharmaceuticals. The article on psuedoephedrine does mention that it should be used with caution in patients with BPH although no mention is made as to whether it has a known anti-cholinergic action as well. The book "Man to Man", by Michael Korda describes the link between OTC cold medications and Prostate disease in a non-clinical fashion. I have personal experience of that result. Men taking prescribed DEXX-amphetamine for ADD have also experienced prostate disorders, again, presumed to be an outcome of anticholinergic activity. I will dig about for some other references.Celsius100 (talk) 01:39, 3 July 2009 (UTC)
These comments are from 5-6 years ago and this hasn't been addressed yet? Here is an PubMed article reference from 1998 I found regarding anticholinergic activity of chlorpheniramine: http://www.ncbi.nlm.nih.gov/m/pubmed/9578932/
I'm editing this on my phone else I would edit the article itself. And it's been years since I've edited an article. I couldn't even remember how to sign this. — Preceding unsigned comment added by Jmcclare (talk • contribs) 02:34, 15 August 2014 (UTC)
The question about anticholinergic action, at least in vitro, is already described in the pharmacodynamic table (see the M1 ... M5 rows). The bigger the number, the weaker it is -- compared with diphenhydramine, it is really really weak! --Artoria2e5 🌉 04:01, 13 September 2024 (UTC)