Talk:Biopharmaceutics Classification System

"Biopharmaceutics Classification System of Solubility Metric" —Preceding unsigned comment added by 75.209.131.243 (talk) 21:31, 7 November 2010 (UTC)

Solubility, permeability and dissolution

I came to this page knowing virtually knowing about BCS, and have left rather confused. The text seems to first say that there are four classes - based on permeability and solubility. And then says classification based on solubility, permeability and dissolution. I'm left very confused - could anyone clarify? Icarusgeek (talk) 18:13, 19 March 2010 (UTC)

I am not certain myself. However it is clear that solubility and dissolution are closely related. For a compound with a very slow dissolution rate, the time it takes for it to dissolve is longer than the time available in the GI tract when it can be absorbed. Effectively this compound has low solubility regardless of what its equilibrium solubility is. Hence it might be more reasonable to classify compounds as (high solubility/high dissolution rate) vs everything else (high solubility/low dissolution rate + low solubility/high dissolution rate + low solubility/low dissolution rate). Then the combination of two solubility/dissolution groups X two permeability groups = four BCS groups. Boghog (talk) 19:21, 19 March 2010 (UTC)