TSPAN2

TSPAN2
Identifiers
Aliases	TSPAN2, NET3, TSN2, TSPAN-2, tetraspanin 2
External IDs	OMIM: 613133; MGI: 1917997; HomoloGene: 21169; GeneCards: TSPAN2; OMA:TSPAN2 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	115,089,503 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	102,708,829 bp
RNA expression pattern
	Top expressed in
	body of uterus; ; muscle layer of sigmoid colon; ; popliteal artery; ; tibial arteries; ; right coronary artery; ; tail of epididymis; ; Descending thoracic aorta; ; ascending aorta; ; islet of Langerhans; ; gastric mucosa;
	Top expressed in
	ventral tegmental area; ; lateral geniculate nucleus; ; globus pallidus; ; deep cerebellar nuclei; ; left lung lobe; ; lateral hypothalamus; ; right lung; ; medial geniculate nucleus; ; right lung lobe; ; central gray substance of midbrain;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding;
Cellular component	integral component of membrane; myelin sheath; plasma membrane; integral component of plasma membrane; membrane;
Biological process	astrocyte development; myelination; cell surface receptor signaling pathway; axon development; brain development; oligodendrocyte differentiation; inflammatory response; microglia development;
	Sources:Amigo / QuickGO
Orthologs
	10100
	70747
	ENSG00000134198
	ENSMUSG00000027858
	O60636
	Q922J6
	NM_001308315; NM_001308316; NM_005725
	NM_001243132; NM_027533
	NP_001295244; NP_001295245; NP_005716
	NP_001230061; NP_081809
	Wikidata
View/Edit Human	View/Edit Mouse

Tetraspanin-2 is a protein that in humans is encoded by the TSPAN2 gene.^[5]^[6]^[7]

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility.^[7]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000134198 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000027858 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Todd SC, Doctor VS, Levy S (Sep 1998). "Sequences and expression of six new members of the tetraspanin/TM4SF family". Biochim Biophys Acta. 1399 (1): 101–4. doi:10.1016/s0167-4781(98)00087-6. PMID 9714763.
↑ Berditchevski F (Dec 2001). "Complexes of tetraspanins with integrins: more than meets the eye". J Cell Sci. 114 (Pt 23): 4143–51. doi:10.1242/jcs.114.23.4143. PMID 11739647.
1 2 "Entrez Gene: TSPAN2 tetraspanin 2".

External links

TSPAN2 human gene location in the UCSC Genome Browser.
TSPAN2 human gene details in the UCSC Genome Browser.

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000134198 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000027858 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9714763-5] Todd SC, Doctor VS, Levy S (Sep 1998). "Sequences and expression of six new members of the tetraspanin/TM4SF family". Biochim Biophys Acta. 1399 (1): 101–4. doi:10.1016/s0167-4781(98)00087-6. PMID 9714763.

[pmid11739647-6] Berditchevski F (Dec 2001). "Complexes of tetraspanins with integrins: more than meets the eye". J Cell Sci. 114 (Pt 23): 4143–51. doi:10.1242/jcs.114.23.4143. PMID 11739647.

[entrez-7] 1 2 "Entrez Gene: TSPAN2 tetraspanin 2".

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v t e Protein: cell membrane proteins (other than Cell surface receptor, enzymes, and cytoskeleton)
Arrestin	SAG ARRB1 ARRB2 ARR3
Membrane-spanning 4A	MS4A1 MS4A2 MS4A3 MS4A4A MS4A4E MS4A5 MS4A6A MS4A6E MS4A7 MS4A8B MS4A9 MS4A10 MS4A12 MS4A13 MS4A14 MS4A15 MS4A18
Myelin	Myelin basic protein PMP2 Myelin proteolipid protein PLP1 Myelin oligodendrocyte glycoprotein Myelin-associated glycoprotein Myelin protein zero
Pulmonary surfactant	Pulmonary surfactant-associated protein B Pulmonary surfactant-associated protein C
Tetraspanin	TSPAN1 TSPAN2 TSPAN3 TSPAN4 TSPAN5 TSPAN6 TSPAN7 TSPAN8 TSPAN9 TSPAN10 TSPAN11 TSPAN12 TSPAN13 TSPAN14 TSPAN15 TSPAN16 TSPAN17 TSPAN18 TSPAN19 TSPAN20 TSPAN21 TSPAN22 TSPAN23 TSPAN24 TSPAN25 TSPAN26 TSPAN27 TSPAN28 TSPAN29 TSPAN30 TSPAN31 TSPAN32 TSPAN33 TSPAN34
Other/ungrouped	Calnexin LDL-receptor-related protein-associated protein Neurofibromin 2 Presenilin PSEN1 PSEN2 HFE Phospholipid transfer proteins Dysferlin STRC OTOF
see also other cell membrane protein disorders

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TSPAN2

References

Further reading

External links