// Workers AI · dad joke modeWhat did TRIM69 say to its date? "You trim my heart.

TRIM69
Identifiers
Aliases	TRIM69, HSD-34, HSD34, RNF36, Trif, tripartite motif containing 69
External IDs	OMIM: 616017; MGI: 1918178; HomoloGene: 18827; GeneCards: TRIM69; OMA:TRIM69 - orthologs
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4NQJ
Enzyme activity
Gene location (Human)
Chr.	Chromosome 15 (human)
End	44,767,829 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	122,009,508 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; epithelium of colon; ; thymus; ; prefrontal cortex; ; muscle of thigh; ; left testis; ; skeletal muscle tissue; ; putamen; ; left ventricle; ; caudate nucleus;
	Top expressed in
	spermatid; ; spermatocyte; ; seminiferous tubule; ; embryo; ; embryo; ; blastocyst; ; morula; ; jejunum; ; endocrine system; ; pancreas;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; metal ion binding; ubiquitin-protein transferase activity; transferase activity;
Cellular component	cytoplasm; nuclear speck; nucleus; cytosol;
Biological process	protein ubiquitination; apoptotic process; protein polyubiquitination;
	Sources:Amigo / QuickGO
Orthologs
	140691
	70928
	ENSG00000278211; ENSG00000185880
	ENSMUSG00000033368
	Q86WT6
	Q80X56
	NM_182985; NM_001301144; NM_001301145; NM_001301146; NM_080745
	NM_080510; NM_001379369
	NP_001288073; NP_001288074; NP_001288075; NP_542783; NP_892030
	NP_536771; NP_001366298
	Wikidata
View/Edit Human	View/Edit Mouse

Tripartite motif containing 69 is a protein that in humans is encoded by the TRIM69 gene.^[5]

Function

This gene encodes a member of the RING-B-box-coiled-coil (RBCC) family and encodes a protein with an N-terminal RING finger motif, a PRY domain and a C-terminal SPRY domain. The mouse ortholog of this gene is specifically expressed in germ cells at the round spermatid stages during spermatogenesis and, when overexpressed, induces apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described.

References

1 2 3 ENSG00000185880 GRCh38: Ensembl release 89: ENSG00000278211, ENSG00000185880 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000033368 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: Tripartite motif containing 69". Retrieved 2016-02-16.

External links

PDBe-KB provides an overview of all the structure information available in the PDB for Human E3 ubiquitin-protein ligase TRIM69

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// Workers AI · dad joke modeWhat did TRIM69 say to its date? "You trim my heart.

Function

References

External links

Further reading