TRA2B

TRA2B
Identifiers
Aliases	TRA2B, Htra2-beta, PPP1R156, SFRS10, SRFS10, TRA2-BETA, TRAN2B, transformer 2 beta homolog (Drosophila), transformer 2 beta homolog
External IDs	OMIM: 602719; MGI: 106016; GeneCards: TRA2B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2CQC, 2KXN, 2RRA, 2RRB
Gene location (Human) Chr. Chromosome 3 (human) Band 3q27.2 Start 185,914,558 bp End 185,938,103 bp
Gene location (Mouse) Chr. Chromosome 16 (mouse) Band 16 B1|16 13.18 cM Start 22,063,299 bp End 22,084,755 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in germinal epithelium parietal pleura ventricular zone embryo visceral pleura endothelial cell ganglionic eminence amniotic fluid tibia epithelium of nasopharynx Top expressed in tail of embryo genital tubercle ventricular zone yolk sac embryo embryo spermatocyte neural layer of retina morula blastocyst More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleic acid binding mRNA binding protein binding poly-purine tract binding RNA binding protein domain specific binding pre-mRNA binding identical protein binding Cellular component nucleus nuclear inner membrane nucleoplasm spliceosomal complex ribonucleoprotein complex Biological process RNA splicing, via transesterification reactions RNA splicing cerebral cortex regionalization mRNA processing negative regulation of mRNA splicing, via spliceosome embryonic brain development mRNA splicing, via spliceosome positive regulation of mRNA splicing, via spliceosome regulation of alternative mRNA splicing, via spliceosome regulation of RNA splicing protein complex oligomerization cellular response to glucose stimulus Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 6434 20462 Ensembl ENSG00000136527 ENSMUSG00000022858 UniProt P62995 P62996 RefSeq (mRNA) NM_001243879 NM_004593 NM_009186 NM_001330554 NM_001330555 RefSeq (protein) NP_001230808 NP_004584 NP_001317483 NP_001317484 NP_033212 Location (UCSC) Chr 3: 185.91 – 185.94 Mb Chr 16: 22.06 – 22.08 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Transformer-2 protein homolog beta, also known as TRA2B previously known as splicing factor, arginine/serine-rich 10 (transformer 2 homolog, Drosophila) (SFRS10), is a protein that in humans is encoded by the TRA2B gene.

TRA2B contains a poison exon whose inclusion is autoregulated by TRA2B protein. Proper regulation of poison exon inclusion in TRA2B is important for T cell fate.

Interactions

TRA2B has been shown to interact with RBMX.

Further reading

• Matsuo N, Ogawa S, Imai Y, Takagi T, Tohyama M, Stern D, et al. (November 1995). "Cloning of a novel RNA binding polypeptide (RA301) induced by hypoxia/reoxygenation". The Journal of Biological Chemistry. 270 (47): 28216–28222. doi:10.1074/jbc.270.47.28216. PMID 7499316.
• Lennon G, Auffray C, Polymeropoulos M, Soares MB (1996). "The I.M.A.G.E. Consortium: an integrated molecular analysis of genomes and their expression". Genomics. 33 (1): 151–152. doi:10.1006/geno.1996.0177. PMID 8617505.
• Beil B, Screaton G, Stamm S (1997). "Molecular cloning of htra2-beta-1 and htra2-beta-2, two human homologs of tra-2 generated by alternative splicing". DNA and Cell Biology. 16 (6): 679–690. doi:10.1089/dna.1997.16.679. PMID 9212162.
• Imai Y, Matsuo N, Ogawa S, Tohyama M, Takagi T (January 1998). "Cloning of a gene, YT521, for a novel RNA splicing-related protein induced by hypoxia/reoxygenation". Brain Research. Molecular Brain Research. 53 (1–2): 33–40. doi:10.1016/S0169-328X(97)00262-3. PMID 9473574.
• Tacke R, Tohyama M, Ogawa S, Manley JL (1998). "Human Tra2 proteins are sequence-specific activators of pre-mRNA splicing". Cell. 93 (1): 139–148. doi:10.1016/S0092-8674(00)81153-8. PMID 9546399. S2CID 15384749.
• Eldridge AG, Li Y, Sharp PA, Blencowe BJ (1999). "The SRm160/300 splicing coactivator is required for exon-enhancer function". Proceedings of the National Academy of Sciences of the United States of America. 96 (11): 6125–6130. Bibcode:1999PNAS...96.6125E. doi:10.1073/pnas.96.11.6125. PMC 26846. PMID 10339552.
• Lai MC, Lin RI, Huang SY, Tsai CW, Tarn WY (March 2000). "A human importin-beta family protein, transportin-SR2, interacts with the phosphorylated RS domain of SR proteins". The Journal of Biological Chemistry. 275 (11): 7950–7957. doi:10.1074/jbc.275.11.7950. PMID 10713112.
• Venables JP, Elliott DJ, Makarova OV, Makarov EM, Cooke HJ, Eperon IC (March 2000). "RBMY, a probable human spermatogenesis factor, and other hnRNP G proteins interact with Tra2beta and affect splicing". Human Molecular Genetics. 9 (5): 685–694. doi:10.1093/hmg/9.5.685. PMID 10749975.
• Helmken C, Wirth B (2001). "Exclusion of Htra2-beta1, an up-regulator of full-length SMN2 transcript, as a modifying gene for spinal muscular atrophy". Human Genetics. 107 (6): 554–558. doi:10.1007/s004390000409. PMID 11153908. S2CID 30528707.
• Young PJ, DiDonato CJ, Hu D, Kothary R, Androphy EJ, Lorson CL (March 2002). "SRp30c-dependent stimulation of survival motor neuron (SMN) exon 7 inclusion is facilitated by a direct interaction with hTra2 beta 1". Human Molecular Genetics. 11 (5): 577–587. doi:10.1093/hmg/11.5.577. PMID 11875052.
• Tran Q, Coleman TP, Roesser JR (2003). "Human transformer 2beta and SRp55 interact with a calcitonin-specific splice enhancer". Biochimica et Biophysica Acta. 1625 (2): 141–152. doi:10.1016/S0167-4781(02)00600-0. PMID 12531473.
• El Yazidi-Belkoura I, Adriaenssens E, Dollé L, Descamps S, Hondermarck H (May 2003). "Tumor necrosis factor receptor-associated death domain protein is involved in the neurotrophin receptor-mediated antiapoptotic activity of nerve growth factor in breast cancer cells". The Journal of Biological Chemistry. 278 (19): 16952–16956. doi:10.1074/jbc.M300631200. PMID 12604596.
• Jiang Z, Tang H, Havlioglu N, Zhang X, Stamm S, Yan R, et al. (May 2003). "Mutations in tau gene exon 10 associated with FTDP-17 alter the activity of an exonic splicing enhancer to interact with Tra2 beta". The Journal of Biological Chemistry. 278 (21): 18997–19007. doi:10.1074/jbc.M301800200. PMC 2140226. PMID 12649279.
• Chen X, Guo L, Lin W, Xu P (2004). "Expression of Tra2beta isoforms is developmentally regulated in a tissue- and temporal-specific pattern". Cell Biology International. 27 (6): 491–496. doi:10.1016/S1065-6995(03)00072-6. PMID 12798777. S2CID 44758770.
• Helmken C, Hofmann Y, Schoenen F, Oprea G, Raschke H, Rudnik-Schöneborn S, et al. (December 2003). "Evidence for a modifying pathway in SMA discordant families: reduced SMN level decreases the amount of its interacting partners and Htra2-beta1". Human Genetics. 114 (1): 11–21. doi:10.1007/s00439-003-1025-2. PMID 14520560. S2CID 19872246.
• Li J, Hawkins IC, Harvey CD, Jennings JL, Link AJ, Patton JG (November 2003). "Regulation of alternative splicing by SRrp86 and its interacting proteins". Molecular and Cellular Biology. 23 (21): 7437–7447. doi:10.1128/MCB.23.21.7437-7447.2003. PMC 207616. PMID 14559993.