// Workers AI · dad joke modeWhat did TMEM109 say to its friend? "You're a membrane-able buddy

TMEM109
Identifiers
Aliases	TMEM109, transmembrane protein 109
External IDs	MGI: 1915789; GeneCards: TMEM109
Gene location (Human) Chr. Chromosome 11 (human) Band 11q12.2 Start 60,914,158 bp End 60,923,443 bp
Gene location (Mouse) Chr. Chromosome 19 (mouse) Band 19|19 A Start 10,848,024 bp End 10,859,365 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in thoracic aorta ascending aorta right coronary artery apex of heart Descending thoracic aorta body of uterus left coronary artery tibial nerve popliteal artery tibial arteries Top expressed in ascending aorta aortic valve tunica media of zone of aorta tunica adventitia of aorta conjunctival fornix vastus lateralis muscle internal carotid artery masseter muscle intercostal muscle medial head of gastrocnemius muscle More reference expression data BioGPS n/a
Gene ontology Molecular function voltage-gated ion channel activity molecular function protein binding Cellular component sarcoplasmic reticulum membrane extracellular exosome endoplasmic reticulum membrane nucleus membrane sarcoplasmic reticulum nuclear outer membrane integral component of membrane endoplasmic reticulum Biological process ion transport negative regulation of cell death cellular response to gamma radiation intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator regulation of ion transmembrane transport transport ion transmembrane transport Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 79073 68539 Ensembl ENSG00000110108 ENSMUSG00000034659 UniProt Q9BVC6 Q3UBX0 RefSeq (mRNA) NM_024092 NM_134142 RefSeq (protein) NP_076997 NP_598903 Location (UCSC) Chr 11: 60.91 – 60.92 Mb Chr 19: 10.85 – 10.86 Mb PubMed search
Wikidata
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Transmembrane protein 109 is a protein that in humans is encoded by the TMEM109 gene.

Further reading

• Yamazaki T, Sasaki N, Nishi M, Takeshima H (2010). "Facilitation of DNA damage-induced apoptosis by endoplasmic reticulum protein mitsugumin23". Biochem. Biophys. Res. Commun. 392 (2): 196–200. doi:10.1016/j.bbrc.2010.01.013. PMID 20060811.