TM7SF2

TM7SF2
Identifiers
Aliases	TM7SF2, ANG1, DHCR14A, NET47, transmembrane 7 superfamily member 2, C14SR
External IDs	OMIM: 603414; MGI: 1920416; HomoloGene: 68305; GeneCards: TM7SF2; OMA:TM7SF2 - orthologs
Enzyme activity
Gene location (Human)
Chr.	Chromosome 11 (human)
End	65,116,384 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	6,118,403 bp
RNA expression pattern
	Top expressed in
	right adrenal cortex; ; left adrenal cortex; ; body of pancreas; ; right lobe of liver; ; apex of heart; ; skin of abdomen; ; skin of leg; ; vulva; ; prefrontal cortex; ; left ovary;
	Top expressed in
	left lobe of liver; ; otic vesicle; ; ciliary body; ; spinal ganglia; ; otic placode; ; iris; ; esophagus; ; medial dorsal nucleus; ; neural layer of retina; ; pyloric antrum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	oxidoreductase activity, acting on the CH-CH group of donors; oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor; oxidoreductase activity; delta14-sterol reductase activity; NADP binding;
Cellular component	organelle membrane; integral component of membrane; endoplasmic reticulum membrane; membrane; receptor complex; integral component of plasma membrane; integral component of endoplasmic reticulum membrane; nuclear inner membrane; endoplasmic reticulum; intracellular membrane-bounded organelle;
Biological process	steroid metabolic process; sterol biosynthetic process; lipid metabolism; cholesterol metabolic process; cholesterol biosynthetic process; steroid biosynthetic process; regulation of cholesterol biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	7108
	73166
	ENSG00000149809
	ENSMUSG00000024799
	O76062
	Q71KT5
	NM_001277233; NM_003273
	NM_028454
	NP_001264162; NP_003264
	NP_082730
	Wikidata
View/Edit Human	View/Edit Mouse

Delta(14)-sterol reductase is an enzyme that in humans is encoded by the TM7SF2 gene.^[5]^[6]^[7]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000149809 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024799 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Lemmens IH, Kas K, Merregaert J, Van de Ven WJ (Aug 1998). "Identification and molecular characterization of TM7SF2 in the FAUNA gene cluster on human chromosome 11q13". Genomics. 49 (3): 437–42. doi:10.1006/geno.1998.5296. PMID 9615229.
↑ Lemmens I, Merregaert J, Van de Ven WJ, Kas K, Zhang CX, Giraud S, Wautot V, Buisson N, De Witte K, Salandre J, Lenoir G, Calender A, Parente F, Quincey D, Courseaux A, Carle GF, Gaudray P, De Wit MJ, Lips CJ, Hoppener JW, Khodaei S, Grant AL, Weber G, Kytola S, Thakker RV, et al. (Nov 1997). "Construction of a 1.2-Mb sequence-ready contig of chromosome 11q13 encompassing the multiple endocrine neoplasia type 1 (MEN1) gene. The European Consortium on MEN1". Genomics. 44 (1): 94–100. doi:10.1006/geno.1997.4872. PMID 9286704.
↑ "Entrez Gene: TM7SF2 transmembrane 7 superfamily member 2".

Bennati AM, Castelli M, Della Fazia MA, et al. (2006). "Sterol dependent regulation of human TM7SF2 gene expression: role of the encoded 3beta-hydroxysterol Delta14-reductase in human cholesterol biosynthesis". Biochim. Biophys. Acta. 1761 (7): 677–85. doi:10.1016/j.bbalip.2006.05.004. PMID 16784888.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Prakash A, Kasbekar DP (2002). "Genes encoding chimeras of Neurospora crassa erg-3 and human TM7SF2 proteins fail to complement Neurospora and yeast sterol C-14 reductase mutants". J. Biosci. 27 (2): 105–12. doi:10.1007/BF02703766. PMID 11937680. S2CID 38757194.
Roberti R, Bennati AM, Galli G, et al. (2002). "Cloning and expression of sterol Delta 14-reductase from bovine liver". Eur. J. Biochem. 269 (1): 283–90. doi:10.1046/j.0014-2956.2001.02646.x. PMID 11784322.
Holmer L, Pezhman A, Worman HJ (1999). "The human lamin B receptor/sterol reductase multigene family". Genomics. 54 (3): 469–76. doi:10.1006/geno.1998.5615. PMID 9878250.

This article on a gene on human chromosome 11 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000149809 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024799 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9615229-5] Lemmens IH, Kas K, Merregaert J, Van de Ven WJ (Aug 1998). "Identification and molecular characterization of TM7SF2 in the FAUNA gene cluster on human chromosome 11q13". Genomics. 49 (3): 437–42. doi:10.1006/geno.1998.5296. PMID 9615229.

[pmid9286704-6] Lemmens I, Merregaert J, Van de Ven WJ, Kas K, Zhang CX, Giraud S, Wautot V, Buisson N, De Witte K, Salandre J, Lenoir G, Calender A, Parente F, Quincey D, Courseaux A, Carle GF, Gaudray P, De Wit MJ, Lips CJ, Hoppener JW, Khodaei S, Grant AL, Weber G, Kytola S, Thakker RV, et al. (Nov 1997). "Construction of a 1.2-Mb sequence-ready contig of chromosome 11q13 encompassing the multiple endocrine neoplasia type 1 (MEN1) gene. The European Consortium on MEN1". Genomics. 44 (1): 94–100. doi:10.1006/geno.1997.4872. PMID 9286704.

[entrez-7] "Entrez Gene: TM7SF2 transmembrane 7 superfamily member 2".

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TM7SF2

References

Further reading