TIMM22

TIMM22
Identifiers
Aliases	TIMM22, TEX4, TIM22, translocase of inner mitochondrial membrane 22 homolog (yeast), translocase of inner mitochondrial membrane 22, COXPD43
External IDs	OMIM: 607251; MGI: 1929742; HomoloGene: 32173; GeneCards: TIMM22; OMA:TIMM22 - orthologs
Gene location (Human) Chr. Chromosome 17 (human) Band 17p13.3 Start 997,129 bp End 1,003,671 bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band 11|11 B5 Start 76,297,778 bp End 76,307,118 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in apex of heart gonad left ventricle islet of Langerhans gastrocnemius muscle muscle of thigh placenta right auricle of heart prefrontal cortex stromal cell of endometrium Top expressed in morula morula facial motor nucleus medial ganglionic eminence endocardial cushion neural tube blastocyst motor neuron renal corpuscle fossa More reference expression data BioGPS More reference expression data
Gene ontology Molecular function mitochondrion targeting sequence binding protein binding protein transmembrane transporter activity Cellular component integral component of membrane mitochondrial inner membrane membrane mitochondrion TIM22 mitochondrial import inner membrane insertion complex Biological process protein transport protein targeting to mitochondrion protein insertion into mitochondrial inner membrane protein transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 29928 56322 Ensembl ENSG00000277649 ENSG00000278501 ENSG00000177370 ENSMUSG00000020843 UniProt Q9Y584 Q9CQ85 RefSeq (mRNA) NM_013337 NM_001291161 NM_019818 NM_023355 RefSeq (protein) NP_037469 NP_001278090 NP_062792 NP_075844 Location (UCSC) Chr 17: 1 – 1 Mb Chr 11: 76.3 – 76.31 Mb PubMed search
Wikidata
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Mitochondrial import inner membrane translocase subunit Tim22 is an enzyme that in humans is encoded by the famous TIMM22 gene.

See also

• Mitochondria Inner Membrane Translocase
• TIMM17A
• TIMM23
• TIMM44

Further reading

• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Mühlenbein N, Hofmann S, Rothbauer U, Bauer MF (2004). "Organization and function of the small Tim complexes acting along the import pathway of metabolite carriers into mammalian mitochondria". J. Biol. Chem. 279 (14): 13540–6. doi:10.1074/jbc.M312485200. PMID 14726512.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Kovermann P, Truscott KN, Guiard B, et al. (2002). "Tim22, the essential core of the mitochondrial protein insertion complex, forms a voltage-activated and signal-gated channel". Mol. Cell. 9 (2): 363–73. doi:10.1016/S1097-2765(02)00446-X. PMID 11864609.
• Bauer MF, Rothbauer U, Mühlenbein N, et al. (2000). "The mitochondrial TIM22 preprotein translocase is highly conserved throughout the eukaryotic kingdom". FEBS Lett. 464 (1–2): 41–7. doi:10.1016/S0014-5793(99)01665-8. PMID 10611480. S2CID 27484018.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.