THRSP

THRSP
Identifiers
Aliases	THRSP, LPGP1, Lpgp, S14, SPOT14, THRP, thyroid hormone responsive
External IDs	OMIM: 601926; MGI: 109126; GeneCards: THRSP
Gene location (Human)
Chr.	Chromosome 11 (human)
End	78,068,351 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	97,066,937 bp
RNA expression pattern
	Top expressed in
	skin of thigh; ; skin of arm; ; vena cava; ; vulva; ; right lobe of liver; ; subcutaneous adipose tissue; ; skin of hip; ; lactiferous gland; ; parotid gland; ; synovial joint;
	Top expressed in
	tunica adventitia of aorta; ; brown adipose tissue; ; white adipose tissue; ; lactiferous gland; ; subcutaneous adipose tissue; ; intercostal muscle; ; tunica media of zone of aorta; ; left lobe of liver; ; parotid gland; ; mesenteric lymph nodes;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein homodimerization activity; identical protein binding; protein binding;
Cellular component	cytoplasm; nucleus; nucleoplasm; cytosol;
Biological process	regulation of lipid biosynthetic process; regulation of transcription, DNA-templated; transcription, DNA-templated; lipid metabolism; regulation of triglyceride biosynthetic process; carnitine shuttle; response to bacterium;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	7069
	21835
	ENSG00000151365
	ENSMUSG00000035686
	Q92748
	Q62264
	NM_003251
	NM_009381
	NP_003242
	NP_033407
	Wikidata
View/Edit Human	View/Edit Mouse

Thyroid hormone-inducible hepatic protein is a protein that in humans is encoded by the THRSP gene.^[5]^[6]

Gene

The protein encoded by this gene is similar to the gene product of S14, a rat gene whose expression is limited to liver and adipose tissue and is controlled by nutritional and hormonal factors.

Tissue distribution

This gene has been shown to be expressed in liver and adipocytes, particularly in lipomatous modules. It is also found to be expressed in lipogenic breast cancers, which suggests a role in controlling tumor lipid metabolism.^[6]

Function

Previously, THRSP was among the identified upregulated genes in the prefrontal cortex of spontaneously hypertensive rats (SHR/NCrl) and Wistar-Kyoto (WKY/NCrl) rats which exhibited inattention behavior.^[7] Subsequently, overexpression of THRSP induced inattention, but not hyperactive and impulsive behavior in mice, suggesting that this gene plays a role in the inattention phenotype of ADHD.^[8]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000151365 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000035686 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Grillasca JP, Gastaldi M, Khiri H, Dace A, Peyrol N, Reynier P, et al. (February 1997). "Cloning and initial characterization of human and mouse Spot 14 genes". FEBS Letters. 401 (1): 38–42. doi:10.1016/S0014-5793(96)01433-0. PMID 9003802. S2CID 44575293.
1 2 "Entrez Gene: THRSP thyroid hormone responsive (SPOT14 homolog, rat)".
↑ dela Peña I, Bang M, Lee J, de la Peña JB, Kim BN, Han DH, et al. (September 2015). "Common prefrontal cortical gene expression profiles between adolescent SHR/NCrl and WKY/NCrl rats which showed inattention behavior". Behavioural Brain Research. 291: 268–276. doi:10.1016/j.bbr.2015.05.012. PMID 26048425. S2CID 9853684.
↑ Custodio RJ, Botanas CJ, de la Peña JB, dela Peña IJ, Kim M, Sayson LV, et al. (October 2018). "Overexpression of the Thyroid Hormone-Responsive (THRSP) Gene in the Striatum Leads to the Development of Inattentive-like Phenotype in Mice". Neuroscience. 390: 141–150. doi:10.1016/j.neuroscience.2018.08.008. PMID 30138648. S2CID 52075574.

Cunningham BA, Moncur JT, Huntington JT, Kinlaw WB (1998). ""Spot 14" protein: a metabolic integrator in normal and neoplastic cells". Thyroid. 8 (9): 815–825. doi:10.1089/thy.1998.8.815. PMID 9777755.
Ota Y, Mariash A, Wagner JL, Mariash CN (1997). "Cloning, expression and regulation of the human S14 gene". Molecular and Cellular Endocrinology. 126 (1): 75–81. doi:10.1016/S0303-7207(96)03971-8. PMID 9027365. S2CID 22056127.
Taviaux S, Planells R, Gastaldi M, Torresani J, Grillasca JP (1997). "Assignment of thyroid hormone responsive SPOT 14 homolog (THRSP) to human chromosome 11 bands q13.5-->q14.1 by in situ hybridization". Cytogenetics and Cell Genetics. 76 (3–4): 219–220. doi:10.1159/000134553. PMID 9186528.
Moncur JT, Park JP, Maloney M, Mohandas TK, Kinlaw WB (1997). "Assignment of the "spot 14" gene (THRSP) to human chromosome band 11q13.5 by in situ hybridization". Cytogenetics and Cell Genetics. 78 (2): 131–132. doi:10.1159/000134644. PMID 9371405.
Cunningham BA, Maloney M, Kinlaw WB (1997). "Spot 14 protein-protein interactions: evidence for both homo- and heterodimer formation in vivo". Endocrinology. 138 (12): 5184–5188. doi:10.1210/en.138.12.5184. PMID 9389499.
Moncur JT, Park JP, Memoli VA, Mohandas TK, Kinlaw WB (June 1998). "The "Spot 14" gene resides on the telomeric end of the 11q13 amplicon and is expressed in lipogenic breast cancers: implications for control of tumor metabolism". Proceedings of the National Academy of Sciences of the United States of America. 95 (12): 6989–6994. Bibcode:1998PNAS...95.6989M. doi:10.1073/pnas.95.12.6989. PMC 22712. PMID 9618526.
Campbell MC, Anderson GW, Mariash CN (2004). "Human spot 14 glucose and thyroid hormone response: characterization and thyroid hormone response element identification". Endocrinology. 144 (12): 5242–5248. doi:10.1210/en.2002-0008. PMID 12960053.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, et al. (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–1178. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Chou WY, Cheng YS, Ho CL, Liu ST, Liu PY, Kuo CC, et al. (May 2007). "Human spot 14 protein interacts physically and functionally with the thyroid receptor". Biochemical and Biophysical Research Communications. 357 (1): 133–138. doi:10.1016/j.bbrc.2007.03.103. PMID 17418816.

This article on a gene on human chromosome 11 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000151365 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000035686 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[Grillasca_1997-5] Grillasca JP, Gastaldi M, Khiri H, Dace A, Peyrol N, Reynier P, et al. (February 1997). "Cloning and initial characterization of human and mouse Spot 14 genes". FEBS Letters. 401 (1): 38–42. doi:10.1016/S0014-5793(96)01433-0. PMID 9003802. S2CID 44575293.

[entrez-6] 1 2 "Entrez Gene: THRSP thyroid hormone responsive (SPOT14 homolog, rat)".

[7] Peña I, Bang M, Lee J, de la Peña JB, Kim BN, Han DH, et al. (September 2015). "Common prefrontal cortical gene expression profiles between adolescent SHR/NCrl and WKY/NCrl rats which showed inattention behavior". Behavioural Brain Research. 291: 268–276. doi:10.1016/j.bbr.2015.05.012. PMID 26048425. S2CID 9853684.

[8] Custodio RJ, Botanas CJ, de la Peña JB, dela Peña IJ, Kim M, Sayson LV, et al. (October 2018). "Overexpression of the Thyroid Hormone-Responsive (THRSP) Gene in the Striatum Leads to the Development of Inattentive-like Phenotype in Mice". Neuroscience. 390: 141–150. doi:10.1016/j.neuroscience.2018.08.008. PMID 30138648. S2CID 52075574.

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THRSP

Gene

Tissue distribution

Function

References

Further reading