THG1L

THG1L
Identifiers
Aliases	THG1L, ICF45, IHG-1, hTHG1, tRNA-histidine guanylyltransferase 1 like, SCAR28, IHG1, THG1
External IDs	MGI: 1913878; HomoloGene: 5959; GeneCards: THG1L; OMA:THG1L - orthologs
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3OTB, 3OTC, 3OTD, 3OTE
Enzyme activity
Gene location (Human)
Chr.	Chromosome 5 (human)
End	157,741,449 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	45,846,321 bp
RNA expression pattern
	Top expressed in
	monocyte; ; cartilage tissue; ; stromal cell of endometrium; ; secondary oocyte; ; mucosa of transverse colon; ; rectum; ; sperm; ; ventricular zone; ; testicle; ; gonad;
	Top expressed in
	spermatocyte; ; embryo; ; spermatid; ; epiblast; ; yolk sac; ; zygote; ; embryo; ; genital tubercle; ; tail of embryo; ; secondary oocyte;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; tRNA binding; GTP binding; protein binding; ATP binding; magnesium ion binding; metal ion binding; tRNA guanylyltransferase activity; identical protein binding; nucleotidyltransferase activity;
Cellular component	cytoplasm; cytosol; mitochondrion;
Biological process	tRNA modification; protein homotetramerization; tRNA processing; tRNA 5'-end processing;
	Sources:Amigo / QuickGO
Orthologs
	54974
	66628
	ENSG00000113272
	ENSMUSG00000011254
	Q9NWX6
	Q9CY52
	NM_017872; NM_001317824; NM_001317825; NM_001317826
	NM_001080969; NM_001290737
	NP_001304753; NP_001304754; NP_001304755; NP_060342
	NP_001074438; NP_001277666
	Wikidata
View/Edit Human	View/Edit Mouse

Probable tRNA(His) guanylyltransferase is an enzyme that in humans is encoded by the THG1L gene.^[5]^[6]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000113272 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000011254 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
↑ "Entrez Gene: THG1L tRNA-histidine guanylyltransferase 1-like (S. cerevisiae)".

Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Guo D, Hu K, Lei Y, et al. (2005). "Identification and characterization of a novel cytoplasm protein ICF45 that is involved in cell cycle regulation". J. Biol. Chem. 279 (51): 53498–505. doi:10.1074/jbc.M406737200. PMID 15459185.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.

This article on a gene on human chromosome 5 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000113272 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000011254 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11230166-5] Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.

[entrez-6] "Entrez Gene: THG1L tRNA-histidine guanylyltransferase 1-like (S. cerevisiae)".

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THG1L

References

Further reading