// Workers AI · dad joke modeWhat did TEX11 say to TEX10? You're one thread behind.

TEX11
Identifiers
Aliases	TEX11, TGC1, TSGA3, SPGFX2, testis expressed 11, ZIP4, MZIP4, Spo22, ZIP4H
External IDs	OMIM: 300311; MGI: 1933237; HomoloGene: 49962; GeneCards: TEX11; OMA:TEX11 - orthologs
Gene location (Human) Chr. X chromosome (human) Band Xq13.1 Start 70,528,940 bp End 70,908,711 bp
Gene location (Mouse) Chr. X chromosome (mouse) Band X|X C3 Start 99,882,254 bp End 100,103,273 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sperm gonad body of pancreas testicle right testis left testis Epithelium of choroid plexus mucosa of transverse colon pancreatic epithelial cell mucosa of sigmoid colon Top expressed in spermatid zygote secondary oocyte spermatocyte embryo embryo primary oocyte seminiferous tubule Gonadal ridge iris More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding Cellular component central element condensed nuclear chromosome chromosome synaptonemal complex Biological process fertilization chiasma assembly male meiosis chromosome segregation synaptonemal complex assembly resolution of meiotic recombination intermediates negative regulation of apoptotic process meiosis male meiotic nuclear division male gonad development meiotic gene conversion reciprocal meiotic recombination Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 56159 83558 Ensembl ENSG00000120498 ENSMUSG00000009670 UniProt Q8IYF3 Q14AT2 RefSeq (mRNA) NM_001003811 NM_031276 NM_001167997 NM_031384 RefSeq (protein) NP_001003811 NP_112566 NP_001161469 NP_113561 Location (UCSC) Chr X: 70.53 – 70.91 Mb Chr X: 99.88 – 100.1 Mb PubMed search
Wikidata
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Testis expressed 11 is a protein that in humans is encoded by the TEX11 gene.

Function

This gene is X-linked and is expressed in only male germ cells. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

Further reading

• Wang PJ, McCarrey JR, Yang F, Page DC (April 2001). "An abundance of X-linked genes expressed in spermatogonia". Nat. Genet. 27 (4): 422–6. doi:10.1038/86927. PMID 11279525. S2CID 14200121.
• Aston KI, Krausz C, Laface I, Ruiz-Castané E, Carrell DT (June 2010). "Evaluation of 172 candidate polymorphisms for association with oligozoospermia or azoospermia in a large cohort of men of European descent" (PDF). Hum. Reprod. 25 (6): 1383–97. doi:10.1093/humrep/deq081. PMID 20378615.
• Yatsenko AN, Georgiadis AP, Röpke A, Berman AJ, Jaffe T, Olszewska M, Westernströer B, Sanfilippo J, Kurpisz M, Rajkovic A, Yatsenko SA, Kliesch S, Schlatt S, Tüttelmann F (May 2015). "X-linked TEX11 mutations, meiotic arrest, and azoospermia in infertile men". N. Engl. J. Med. 372 (22): 2097–107. doi:10.1056/NEJMoa1406192. PMC 4470617. PMID 25970010.
• Yang F, Silber S, Leu NA, Oates RD, Marszalek JD, Skaletsky H, Brown LG, Rozen S, Page DC, Wang PJ (September 2015). "TEX11 is mutated in infertile men with azoospermia and regulates genome-wide recombination rates in mouse". EMBO Mol Med. 7 (9): 1198–210. doi:10.15252/emmm.201404967. PMC 4568952. PMID 26136358.
• Yang F, Silber S, Leu NA, Oates RD, Marszalek JD, Skaletsky H, Brown LG, Rozen S, Page DC, Wang PJ (September 2015). "TEX11 is mutated in infertile men with azoospermia and regulates genome-wide recombination rates in mouse". EMBO Mol Med. 7 (9): 1198–210. doi:10.15252/emmm.201404967. PMC 4568952. PMID 26136358.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.