// Workers AI · dad joke modeWhat did TDRD7 say to its date? "You're a gene-ius match

TDRD7
Identifiers
Aliases	TDRD7, CATC4, CTRCT36, PCTAIRE2BP, TRAP, tudor domain containing 7
External IDs	OMIM: 611258; MGI: 2140279; HomoloGene: 8618; GeneCards: TDRD7; OMA:TDRD7 - orthologs
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3RCO
Gene location (Human)
Chr.	Chromosome 9 (human)
End	97,496,125 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	46,034,761 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; jejunal mucosa; ; retinal pigment epithelium; ; internal globus pallidus; ; sperm; ; pars reticulata; ; monocyte; ; duodenum; ; testicle; ; middle frontal gyrus;
	Top expressed in
	epithelium of lens; ; spermatid; ; neural layer of retina; ; seminiferous tubule; ; spermatocyte; ; retinal pigment epithelium; ; granulocyte; ; mucous cell of stomach; ; intestinal villus; ; jejunum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	mRNA binding; protein binding; protein N-terminus binding; RNA binding;
Cellular component	cytoplasm; chromatoid body; mitochondrial matrix; ribonucleoprotein granule;
Biological process	posttranscriptional regulation of gene expression; cell differentiation; lens fiber cell differentiation; lens morphogenesis in camera-type eye; spermatogenesis;
	Sources:Amigo / QuickGO
Orthologs
	23424
	100121
	ENSG00000196116
	ENSMUSG00000035517
	Q8NHU6
	Q8K1H1
	NM_001302884; NM_014290
	NM_001290475; NM_146142; NM_001355189
	NP_001289813; NP_055105
	NP_001277404; NP_666254; NP_001342118
	Wikidata
View/Edit Human	View/Edit Mouse

Tudor domain-containing protein 7 is a protein that in humans is encoded by the TDRD7 gene.^[5]^[6]

In melanocytic cells TDRD7 gene expression may be regulated by MITF.^[7]

Gene polymorphism

Various single nucleotide polymorphisms (SNPs) of the TDRD7 gene have been identified and for some of them an association with lower susceptibility to age-related cataract was shown.^[8]

Interactions

TDRD7 has been shown to interact with TACC1.^[9]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000196116 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000035517 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA (Dec 2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
↑ "Entrez Gene: TDRD7 tudor domain containing 7".
↑ Hoek KS, Schlegel NC, Eichhoff OM, Widmer DS, Praetorius C, Einarsson SO, Valgeirsdottir S, Bergsteinsdottir K, Schepsky A, Dummer R, Steingrimsson E (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971. S2CID 24698373.
↑ Zheng C, Wu M, He CY, An XJ, Sun M, Chen CL, Ye J (Feb 2014). "RNA granule component TDRD7 gene polymorphisms in a Han Chinese population with age-related cataract". J. Int. Med. Res. 42 (1): 153–63. doi:10.1177/0300060513504702. PMID 24435515.
↑ Conte N, Delaval B, Ginestier C, Ferrand A, Isnardon D, Larroque C, Prigent C, Séraphin B, Jacquemier J, Birnbaum D (Nov 2003). "TACC1-chTOG-Aurora A protein complex in breast cancer". Oncogene. 22 (50): 8102–16. doi:10.1038/sj.onc.1206972. PMID 14603251. S2CID 10536264.

External links

Overview of all the structural information available in the PDB for UniProt: Q8NHU6 (Human Tudor domain-containing protein 7) at the PDBe-KB.
Overview of all the structural information available in the PDB for UniProt: Q8K1H1 (Mouse Tudor domain-containing protein 7) at the PDBe-KB.

This article on a gene on human chromosome 9 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000196116 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000035517 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12477932-5] Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA (Dec 2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

[entrez-6] "Entrez Gene: TDRD7 tudor domain containing 7".

[pmid19067971-7] Hoek KS, Schlegel NC, Eichhoff OM, Widmer DS, Praetorius C, Einarsson SO, Valgeirsdottir S, Bergsteinsdottir K, Schepsky A, Dummer R, Steingrimsson E (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971. S2CID 24698373.

[pmid_=_24435515-8] Zheng C, Wu M, He CY, An XJ, Sun M, Chen CL, Ye J (Feb 2014). "RNA granule component TDRD7 gene polymorphisms in a Han Chinese population with age-related cataract". J. Int. Med. Res. 42 (1): 153–63. doi:10.1177/0300060513504702. PMID 24435515.

[pmid14603251-9] Conte N, Delaval B, Ginestier C, Ferrand A, Isnardon D, Larroque C, Prigent C, Séraphin B, Jacquemier J, Birnbaum D (Nov 2003). "TACC1-chTOG-Aurora A protein complex in breast cancer". Oncogene. 22 (50): 8102–16. doi:10.1038/sj.onc.1206972. PMID 14603251. S2CID 10536264.

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// Workers AI · dad joke modeWhat did TDRD7 say to its date? "You're a gene-ius match

Gene polymorphism

Interactions

References

Further reading

External links