TARBP1

TARBP1
Identifiers
Aliases	TARBP1, TRM3, TRP-185, TRP185, TAR (HIV-1) RNA binding protein 1, TRMT3
External IDs	OMIM: 605052; MGI: 4936930; HomoloGene: 38082; GeneCards: TARBP1; OMA:TARBP1 - orthologs
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2HA8
Enzyme activity EC # BRENDA ExPASy KEGG MetaCyc 2.1.1.34 ↗ ↗ ↗ ↗
Gene location (Human) Chr. Chromosome 1 (human) Band 1q42.2 Start 234,391,313 bp End 234,479,179 bp
Gene location (Mouse) Chr. Chromosome 8 (mouse) Band 8|8 E2 Start 127,152,068 bp End 127,201,804 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right hemisphere of cerebellum right uterine tube right frontal lobe Brodmann area 9 nucleus accumbens rectum pituitary gland anterior pituitary caudate nucleus body of pancreas Top expressed in aortic valve hair follicle ascending aorta cumulus cell Paneth cell primitive streak secondary oocyte primary oocyte ureter tail of embryo More reference expression data BioGPS More reference expression data
Gene ontology Molecular function methyltransferase activity RNA methyltransferase activity transferase activity tRNA (guanine) methyltransferase activity RNA binding rRNA (guanosine-2'-O-)-methyltransferase activity Cellular component nucleus Biological process regulation of transcription by RNA polymerase II methylation RNA processing tRNA methylation enzyme-directed rRNA 2'-O-methylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6894 212728 Ensembl ENSG00000059588 ENSMUSG00000090290 UniProt Q13395 E9Q368 RefSeq (mRNA) NM_005646 NM_001159907 RefSeq (protein) NP_005637 NP_001153379 Location (UCSC) Chr 1: 234.39 – 234.48 Mb Chr 8: 127.15 – 127.2 Mb PubMed search
Wikidata
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Probable methyltransferase TARBP1 is an enzyme that in humans is encoded by the TARBP1 gene.

HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. This element forms a stable stem-loop structure and can be bound by either the protein encoded by this gene or by RNA polymerase II. This protein may act to disengage RNA polymerase II from TAR during transcriptional elongation. Alternatively spliced transcripts of this gene may exist, but their full-length natures have not been determined.

Further reading

• Sheline CT, Milocco LH, Jones KA (1992). "Two distinct nuclear transcription factors recognize loop and bulge residues of the HIV-1 TAR RNA hairpin". Genes Dev. 5 (12B): 2508–20. doi:10.1101/gad.5.12b.2508. PMID 1752441.
• Wu-Baer F, Sigman D, Gaynor RB (1995). "Specific binding of RNA polymerase II to the human immunodeficiency virus trans-activating region RNA is regulated by cellular cofactors and Tat". Proc. Natl. Acad. Sci. U.S.A. 92 (16): 7153–7. Bibcode:1995PNAS...92.7153W. doi:10.1073/pnas.92.16.7153. PMC 41297. PMID 7638159.
• Wu-Baer F, Lane WS, Gaynor RB (1996). "Identification of a group of cellular cofactors that stimulate the binding of RNA polymerase II and TRP-185 to human immunodeficiency virus 1 TAR RNA". J. Biol. Chem. 271 (8): 4201–8. doi:10.1074/jbc.271.8.4201. PMID 8626763.
• Wu-Baer F, Lane WS, Gaynor RB (1996). "The cellular factor TRP-185 regulates RNA polymerase II binding to HIV-1 TAR RNA". EMBO J. 14 (23): 5995–6009. doi:10.1002/j.1460-2075.1995.tb00288.x. PMC 394719. PMID 8846792.
• Yedavalli VS, Benkirane M, Jeang KT (2003). "Tat and trans-activation-responsive (TAR) RNA-independent induction of HIV-1 long terminal repeat by human and murine cyclin T1 requires Sp1". J. Biol. Chem. 278 (8): 6404–10. doi:10.1074/jbc.M209162200. PMID 12458222.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.