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// Workers AI · dad joke modeWhat did Syncollin say to its friend? Let's sync up.

From Wikipedia, the free encyclopedia
SYCN
Identifiers
AliasesSYCN, INSSA1, SYL, syncollin
External IDsMGI: 1915666; GeneCards: SYCN
Orthologs
DatabasesNCBI: entry; OMA: entry
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001080468

NM_026716

RefSeq (protein)

NP_001073937

NP_080992

Location (UCSC)Chr 19: 39.2 – 39.2 MbChr 7: 28.24 – 28.24 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Syncollin is a protein that in humans is encoded by the SYCN gene.[5] This protein is found in the acinar cells of the pancreas, and is involved their secretion of digestive enzymes (via exocytosis).[6] Inside of acinar cells, syncollin is found in the membranes of zymogen granules which contain active and inactive digestive enzymes.[6] It functions to regulate the merging of these granules, but does not appear to be strictly necessary for their formation.[7]

Interactions

[edit]

Synocollin has been found to interact with GP2,[6][7] a protein secreted by acinar cells which may have an immune function.[8]

References

[edit]
  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000179751 – Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000084174 – Ensembl, May 2017
  3. ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ↑ "SYCN syncollin". Entrez Gene. NCBI. Retrieved 2026-09-17.
  6. 1 2 3 "Syncollin". uniprot.org. UniProt consortium. Retrieved 2026-09-17.
  7. 1 2 Gómez-Lázaro M, Rinn C, Aroso M, Amado F, Schrader M (2010-10-01). "Proteomic analysis of zymogen granules" (PDF). Expert review of proteomics. 7 (5): 735–47. doi:10.1586/epr.10.31.
  8. ↑ "Pancreatic secretory granule membrane major glycoprotein GP2". uniprot.org. UniProt consortium. Retrieved 2026-09-17.