Super elongation complex
The super elongation complex (SEC) is a protein complex that regulates the transcription of genes.[1]
The SEC helps RNA polymerase II resume transcription after pausing near the start of a gene, allowing it to continue synthesizing RNA. Its dysregulation can promote abnormal transcription that results in cancer.[1][2] In acute leukemia, KMT2A::AFF1 or KMT2A::MLLT1 fusion proteins can inappropriately recruit SEC components to KMT2A target genes, thus promoting sustained transcription of genes such as HOXA9 that drive leukemia.[2]
Components of the super elongation complex include AFF1, MLLT1/ENL, ELL and the positive transcription elongation factor b (P-TEFb).[2]
See also
[edit]References
[edit]- 1 2 Wu X, Xie Y, Zhao K, Lu J (2023). "Targeting the super elongation complex for oncogenic transcription driven tumor malignancies: Progress in structure, mechanisms and small molecular inhibitor discovery". Advances in Cancer Research. 158: 387–421. doi:10.1016/bs.acr.2022.12.007. PMID 36990537.
- 1 2 3 Schurer A, Glushakow-Smith SG, Gritsman K (February 2025). "Targeting chromatin modifying complexes in acute myeloid leukemia". Stem Cells Translational Medicine. 14 (2) szae089. doi:10.1093/stcltm/szae089. PMC 11878770. PMID 39607901.
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