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SYNPR
Identifiers
Aliases	SYNPR, SPO, synaptoporin
External IDs	MGI: 1919253; GeneCards: SYNPR
Gene location (Human)
Chr.	Chromosome 3 (human)
End	63,616,924 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	9,184,983 bp
RNA expression pattern
	Top expressed in
	lateral nuclear group of thalamus; ; cerebellar vermis; ; nucleus accumbens; ; external globus pallidus; ; Brodmann area 46; ; middle temporal gyrus; ; caudate nucleus; ; cerebellar hemisphere; ; superior frontal gyrus; ; Brodmann area 23;
	Top expressed in
	habenula; ; olfactory tubercle; ; dorsomedial hypothalamic nucleus; ; dentate gyrus; ; nucleus accumbens; ; globus pallidus; ; dentate gyrus of hippocampal formation granule cell; ; suprachiasmatic nucleus; ; lobe of cerebellum; ; neural layer of retina;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; syntaxin-1 binding;
Cellular component	synapse; membrane; cell junction; cytoplasmic vesicle; integral component of synaptic vesicle membrane; synaptic vesicle membrane; neuron projection; integral component of membrane; synaptic vesicle;
Biological process	transport;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	132204
	72003
	ENSG00000163630
	ENSMUSG00000056296
	Q8TBG9
	Q8BGN8
	NM_001130003; NM_144642
	NM_001163032; NM_028052
	NP_001123475; NP_653243
	NP_001156504; NP_082328
	Wikidata
View/Edit Human	View/Edit Mouse

Synaptoporin is a protein that in humans is encoded by the SYNPR gene.^[5]^[6]^[7] It is expressed in the brain in small synaptic vesicles and predicted to modulate chemical synaptic transmission.^[8]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000163630 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000056296 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Leube RE (Aug 1994). "Expression of the synaptophysin gene family is not restricted to neuronal and neuroendocrine differentiation in rat and human". Differentiation. 56 (3): 163–71. doi:10.1046/j.1432-0436.1994.5630163.x. PMID 8034131.
↑ Dai J, Ji C, Gu S, Wu Q, Wang L, Xu J, Zeng L, Ye X, Yin G, Xie Y, Mao Y (Sep 2003). "Cloning and sequence analysis of the human cDNA encoding the synaptoporin (delta), a highly conservative synaptic vesicle protein". Mol Biol Rep. 30 (3): 185–91. doi:10.1023/A:1024907723000. PMID 12974474. S2CID 40874195.
↑ "Entrez Gene: SYNPR synaptoporin".
↑ "SYNPR Gene - GeneCards". GeneCards. Weizman Institute of Science. Retrieved 6 May 2026.

Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Singec I, Knoth R, Ditter M, et al. (2002). "Synaptic vesicle protein synaptoporin is differently expressed by subpopulations of mouse hippocampal neurons". J. Comp. Neurol. 452 (2): 139–53. doi:10.1002/cne.10371. PMID 12271488. S2CID 30492933.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Tran MH, Yamada K, Nakajima A, et al. (2004). "Tyrosine nitration of a synaptic protein synaptophysin contributes to amyloid beta-peptide-induced cholinergic dysfunction". Mol. Psychiatry. 8 (4): 407–12. doi:10.1038/sj.mp.4001240. PMID 12740598. S2CID 23487661.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.

This article on a gene on human chromosome 3 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000163630 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000056296 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8034131-5] Leube RE (Aug 1994). "Expression of the synaptophysin gene family is not restricted to neuronal and neuroendocrine differentiation in rat and human". Differentiation. 56 (3): 163–71. doi:10.1046/j.1432-0436.1994.5630163.x. PMID 8034131.

[pmid12974474-6] Dai J, Ji C, Gu S, Wu Q, Wang L, Xu J, Zeng L, Ye X, Yin G, Xie Y, Mao Y (Sep 2003). "Cloning and sequence analysis of the human cDNA encoding the synaptoporin (delta), a highly conservative synaptic vesicle protein". Mol Biol Rep. 30 (3): 185–91. doi:10.1023/A:1024907723000. PMID 12974474. S2CID 40874195.

[entrez-7] "Entrez Gene: SYNPR synaptoporin".

[8] "SYNPR Gene - GeneCards". GeneCards. Weizman Institute of Science. Retrieved 6 May 2026.

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References

Further reading