// Workers AI · dad joke modeWhy did STYK1 go to therapy? It had a lot of "tyking" issues.

STYK1
Identifiers
Aliases	STYK1, NOK, SuRTK106, serine/threonine/tyrosine kinase 1
External IDs	OMIM: 611433; MGI: 2141396; HomoloGene: 49545; GeneCards: STYK1; OMA:STYK1 - orthologs
Enzyme activity
Gene location (Human)
Chr.	Chromosome 12 (human)
End	10,674,318 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	131,330,560 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; amniotic fluid; ; pancreatic ductal cell; ; rectum; ; middle temporal gyrus; ; Brodmann area 23; ; mucosa of colon; ; mucosa of transverse colon; ; mucosa of sigmoid colon; ; palpebral conjunctiva;
	Top expressed in
	zygote; ; jejunum; ; left colon; ; secondary oocyte; ; primary oocyte; ; duodenum; ; Paneth cell; ; ileum; ; granulocyte; ; epithelium of stomach;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; protein tyrosine kinase activity; signaling receptor binding; non-membrane spanning protein tyrosine kinase activity; protein binding; ATP binding; kinase activity;
Cellular component	integral component of membrane; extrinsic component of cytoplasmic side of plasma membrane; plasma membrane; membrane;
Biological process	peptidyl-tyrosine autophosphorylation; cell differentiation; protein phosphorylation; innate immune response; cell migration; regulation of cell population proliferation; phosphorylation; chemotaxis; cell adhesion; epidermal growth factor receptor signaling pathway; regulation of mast cell degranulation; peptidyl-tyrosine phosphorylation;
	Sources:Amigo / QuickGO
Orthologs
	55359
	243659
	ENSG00000060140
	ENSMUSG00000032899
	Q6J9G0
	Q6J9G1
	NM_018423
	NM_172891
	NP_060893
	NP_766479
	Wikidata
View/Edit Human	View/Edit Mouse

Tyrosine-protein kinase STYK1 is an enzyme that in humans is encoded by the STYK1 gene.^[5]^[6]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000060140 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000032899 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Ye X, Ji C, Huang Q, Cheng C, Tang R, Xu J, Zeng L, Dai J, Wu Q, Gu S, Xie Y, Mao Y (Jul 2003). "Isolation and characterization of a human putative receptor protein kinase cDNA STYK1". Mol Biol Rep. 30 (2): 91–6. doi:10.1023/A:1023934017174. PMID 12841579. S2CID 29762417.
↑ "Entrez Gene: STYK1 serine/threonine/tyrosine kinase 1".

Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Liu L, Yu XZ, Li TS, et al. (2004). "A novel protein tyrosine kinase NOK that shares homology with platelet- derived growth factor/fibroblast growth factor receptors induces tumorigenesis and metastasis in nude mice". Cancer Res. 64 (10): 3491–9. doi:10.1158/0008-5472.CAN-03-2106. PMID 15150103.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
Amachika T, Kobayashi D, Moriai R, et al. (2007). "Diagnostic relevance of overexpressed mRNA of novel oncogene with kinase-domain (NOK) in lung cancers". Lung Cancer. 56 (3): 337–40. doi:10.1016/j.lungcan.2007.01.002. PMID 17298854.

This article on a gene on human chromosome 12 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000060140 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000032899 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12841579-5] Ye X, Ji C, Huang Q, Cheng C, Tang R, Xu J, Zeng L, Dai J, Wu Q, Gu S, Xie Y, Mao Y (Jul 2003). "Isolation and characterization of a human putative receptor protein kinase cDNA STYK1". Mol Biol Rep. 30 (2): 91–6. doi:10.1023/A:1023934017174. PMID 12841579. S2CID 29762417.

[entrez-6] "Entrez Gene: STYK1 serine/threonine/tyrosine kinase 1".

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// Workers AI · dad joke modeWhy did STYK1 go to therapy? It had a lot of "tyking" issues.

References

Further reading