STARD3NL

STARD3NL
Identifiers
Aliases	STARD3NL, MENTHO, STARD3 N-terminal like
External IDs	OMIM: 611759; MGI: 1923455; GeneCards: STARD3NL
Gene location (Human) Chr. Chromosome 7 (human) Band 7p14.1 Start 38,178,245 bp End 38,230,670 bp
Gene location (Mouse) Chr. Chromosome 13 (mouse) Band 13|13 A2 Start 19,357,676 bp End 19,395,795 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte pancreatic epithelial cell endothelial cell mucosa of ileum islet of Langerhans ganglionic eminence hypothalamus C1 segment ventricular zone substantia nigra Top expressed in basilar part of occipital bone splanchnocranium zygote hyoid bone right kidney rib yolk sac secondary oocyte endocardial cushion seminal vesicula More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding cholesterol binding protein homodimerization activity Cellular component lysosomal membrane membrane integral component of membrane endosome cytosol intracellular membrane-bounded organelle endoplasmic reticulum membrane late endosome membrane organelle membrane contact site endoplasmic reticulum-endosome membrane contact site Biological process C21-steroid hormone biosynthetic process vesicle tethering to endoplasmic reticulum Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 83930 76205 Ensembl ENSG00000010270 ENSMUSG00000003062 UniProt O95772 Q9DCI3 RefSeq (mRNA) NM_032016 NM_001363339 NM_001363340 NM_001363343 NM_001363344 NM_001363345 NM_001363346 NM_001363347 NM_024270 NM_001347485 RefSeq (protein) NP_114405 NP_001350268 NP_001350269 NP_001350272 NP_001350273 NP_001350274 NP_001350275 NP_001350276 NP_001334414 NP_077232 Location (UCSC) Chr 7: 38.18 – 38.23 Mb Chr 13: 19.36 – 19.4 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

MENTHO or STARD3 N-terminal like protein (STARD3NL) is an integral membrane protein of unknown function. As the alternate name implies, MENTHO, short for "MLN64 N-terminal homologue", contains a region in its N-terminus similar to that found in STARD3, also known as MLN64, but lacks the StAR-related transfer domain (START) that characterizes all other proteins given the "STARD" (START domain-containing) name. The N-terminal domain is called a MENTAL (MLN64 N-terminal) domain.

Like MLN64, MENTHO is widely expressed in tissues of the body. Within the cell, it localizes to the membranes of late endosomes and may interact there with MLN64. It is suggested that in combination with MLN64, this protein helps regulate the flow of cholesterol through the endosomal pathway.

Further reading

• Sanger Centre T, Washington University Genome Sequencing Cente T (November 1998). "Toward a complete human genome sequence". Genome Research. 8 (11): 1097–1108. doi:10.1101/gr.8.11.1097. PMID 9847074.
• Alpy F, Wendling C, Rio MC, Tomasetto C (2003). "MENTHO, an MLN64 homologue devoid of the START domain". The Journal of Biological Chemistry. 277 (52): 50780–50787. doi:10.1074/jbc.M208290200. PMID 12393907.
• Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, et al. (October 2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Research. 13 (10): 2265–2270. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Tuckey RC, Bose HS, Czerwionka I, Miller WL (2004). "Molten globule structure and steroidogenic activity of N-218 MLN64 in human placental mitochondria". Endocrinology. 145 (4): 1700–1707. doi:10.1210/en.2003-1034. PMID 14715710.
• Alpy F, Latchumanan VK, Kedinger V, Janoshazi A, Thiele C, Wendling C, et al. (May 2005). "Functional characterization of the MENTAL domain". The Journal of Biological Chemistry. 280 (18): 17945–17952. doi:10.1074/jbc.M500723200. PMID 15718238.
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, et al. (November 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–648. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.

External links

• STARD3NL+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)