SRRM1
Serine/arginine repetitive matrix protein 1 is a protein that in humans is encoded by the SRRM1 gene.[5][6]
SRRM1 is a component of a splicing-associated regulatory network implicated in chemotherapy resistance in acute myeloid leukemia (AML). In chemoresistant AML cells, hyperphosphorylation of SRRM1 by the kinase families PAK1 and CLK1/4 was reported to alter its scaffolding function and drive alternative splicing programs, including expression of the full-length MAP2K5 isoform, that contribute to chemotherapy resistance.[7]
Interactions
[edit]References
[edit]- 1 2 3 GRCh38: Ensembl release 89: ENSG00000133226 – Ensembl, May 2017
- 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028809 – Ensembl, May 2017
- ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ Blencowe BJ, Issner R, Nickerson JA, Sharp PA (May 1998). "A coactivator of pre-mRNA splicing". Genes Dev. 12 (7): 996–1009. doi:10.1101/gad.12.7.996. PMC 316672. PMID 9531537.
- ↑ "Entrez Gene: SRRM1 serine/arginine repetitive matrix 1".
- ↑ Vaganay C, Ling F, Kelly LM, Charles J, Meslin PA, Pasquer H, Kim R, Passet M, Duchmann M, Pelissier-Menjaud L, Lecourt S, Su AH, Latour E, Bassil CF, Alexe G, Fortin G, Ho Nhat D, Culeux C, Legrand C, Fodil S, Huynh T, Saadallah K, Ramos A, Lombard B, Loew D, Delaney CD, Lonchamp C, Fontaine M, Pacchiardi K, Kocijancic A, Aziez L, Fenouille N, Sebert M, Adès L, Raffoux E, Hemann MT, Clappier E, Benajiba L, Stegmaier K, Wood KC, Itzykson R, Forget A, Lobry C, Puissant A (2026-07-08). "Splicing-associated network PAK1-CLK1/4-SRRM1 is a vulnerability to overcome chemoresistance in human and mouse acute myeloid leukemia". Science Translational Medicine. 18 (857) eadx3847. doi:10.1126/scitranslmed.adx3847. PMID 42418558.
{{cite journal}}: CS1 maint: date and year (link) - ↑ Ajuh P, Kuster B, Panov K, Zomerdijk JC, Mann M, Lamond AI (December 2000). "Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry". EMBO J. 19 (23): 6569–81. doi:10.1093/emboj/19.23.6569. PMC 305846. PMID 11101529.
Further reading
[edit]- Wang HY, Lin W, Dyck JA, Yeakley JM, Songyang Z, Cantley LC, Fu XD (1998). "SRPK2: a differentially expressed SR protein-specific kinase involved in mediating the interaction and localization of pre-mRNA splicing factors in mammalian cells". J. Cell Biol. 140 (4): 737–50. doi:10.1083/jcb.140.4.737. PMC 2141757. PMID 9472028.
- Wilson KF, Fortes P, Singh US, Ohno M, Mattaj IW, Cerione RA (1999). "The nuclear cap-binding complex is a novel target of growth factor receptor-coupled signal transduction". J. Biol. Chem. 274 (7): 4166–73. doi:10.1074/jbc.274.7.4166. PMID 9933612.
- Eldridge AG, Li Y, Sharp PA, Blencowe BJ (1999). "The SRm160/300 splicing coactivator is required for exon-enhancer function". Proc. Natl. Acad. Sci. U.S.A. 96 (11): 6125–30. Bibcode:1999PNAS...96.6125E. doi:10.1073/pnas.96.11.6125. PMC 26846. PMID 10339552.
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External links
[edit]- SRRM1 human gene location in the UCSC Genome Browser.
- SRRM1 human gene details in the UCSC Genome Browser.
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