// Workers AI · dad joke modeWhat did SPIRE1 say to its peer? Let's pire up.
SPIRE1 is a protein that interacts with actin monomers and actin nucleating formin proteins.[1] SPIRE1 was first identified in Drosophila melanogaster.[2] SPIRE1 contains an N-terminal KIND domain which binds formins and four actin-binding WH2 domains which nucleate actin filaments.[3][4]
References
[edit]- ↑ "SPIRE1 - Protein spire homolog 1 - Homo sapiens (Human) - SPIRE1 gene & protein". www.uniprot.org.
- ↑ Manseau, L. J.; Schüpbach, T. (September 19, 1989). "cappuccino and spire: two unique maternal-effect loci required for both the anteroposterior and dorsoventral patterns of the Drosophila embryo". Genes & Development. 3 (9): 1437–1452. doi:10.1101/gad.3.9.1437. PMID 2514120.
- ↑ Quinlan, Margot E.; Heuser, John E.; Kerkhoff, Eugen; Mullins, R. Dyche (2005-01-27). "Drosophila Spire is an actin nucleation factor". Nature. 433 (7024): 382–388. Bibcode:2005Natur.433..382Q. doi:10.1038/nature03241. ISSN 1476-4687. PMID 15674283. S2CID 4424757.
- ↑ Vizcarra, Christina L.; Kreutz, Barry; Rodal, Avital A.; Toms, Angela V.; Lu, Jun; Zheng, Wei; Quinlan, Margot E.; Eck, Michael J. (2011-07-19). "Structure and function of the interacting domains of Spire and Fmn-family formins". Proceedings of the National Academy of Sciences. 108 (29): 11884–11889. Bibcode:2011PNAS..10811884V. doi:10.1073/pnas.1105703108. PMC 3141961. PMID 21730168.