// Workers AI · dad joke modeWhat did SPEN say to its friend? Pen pals.

For other uses, see Spen (disambiguation).

SPEN
Identifiers
Aliases	SPEN, HIAA0929, MINT, RBM15C, SHARP, spen family transcriptional repressor, RATARS
External IDs	OMIM: 613484; MGI: 1891706; HomoloGene: 124461; GeneCards: SPEN; OMA:SPEN - orthologs
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1OW1, 2RT5, 4P6Q
Gene location (Human) Chr. Chromosome 1 (human) Band 1p36.21-p36.13 Start 15,836,095 bp End 15,940,456 bp
Gene location (Mouse) Chr. Chromosome 4 (mouse) Band 4|4 D3 Start 141,195,201 bp End 141,265,908 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone ganglionic eminence optic nerve popliteal artery tibial arteries parotid gland Descending thoracic aorta right hemisphere of cerebellum Achilles tendon ascending aorta Top expressed in internal carotid artery external carotid artery Rostral migratory stream granulocyte ventricular zone genital tubercle tail of embryo crypt of lieberkuhn of small intestine visual cortex neural layer of retina More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding protein binding nucleic acid binding RNA binding transcription corepressor activity Cellular component transcription repressor complex extracellular exosome nucleus nucleoplasm Biological process Notch signaling pathway positive regulation of neurogenesis mRNA splicing, via spliceosome viral process negative regulation of transcription, DNA-templated regulation of transcription, DNA-templated negative regulation of transcription by RNA polymerase II transcription, DNA-templated Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23013 56381 Ensembl ENSG00000065526 ENSMUSG00000040761 UniProt Q96T58 Q62504 RefSeq (mRNA) NM_015001 NM_019763 NM_001347235 RefSeq (protein) NP_055816 NP_001334164 NP_062737 Location (UCSC) Chr 1: 15.84 – 15.94 Mb Chr 4: 141.2 – 141.27 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Msx2-interacting protein is a protein that in humans is encoded by the SPEN gene.

This gene encodes a hormone inducible transcriptional repressor. Repression of transcription by this gene product can occur through interactions with other repressors, by the recruitment of proteins involved in histone deacetylation, or through sequestration of transcriptional activators. The product of this gene contains a carboxy-terminal domain that permits binding to other corepressor proteins. This domain also permits interaction with members of the NuRD complex, a nucleosome remodeling protein complex that contains deacetylase activity. In addition, this repressor contains several RNA recognition motifs that confer binding to a steroid receptor RNA coactivator; this binding can modulate the activity of both liganded and nonliganded steroid receptors.

Interactions

SPEN has been shown to interact with HDAC1, SRA1 and Nuclear receptor co-repressor 2.

Further reading

• Ternovskaia LN, Prokhorova LG, Moroz VM (1977). "[Antagonistic interrelationships between the staphylococci and Sarcina isolated from the upper respiratory tracts of virtually healthy persons]". Antibiotiki. 21 (12): 1072–5. PMID 1020939.
• Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (1): 63–70. doi:10.1093/dnares/6.1.63. PMID 10231032.
• Shi Y, Hon M, Evans RM (2002). "The peroxisome proliferator-activated receptor delta, an integrator of transcriptional repression and nuclear receptor signaling". Proc. Natl. Acad. Sci. U.S.A. 99 (5): 2613–8. Bibcode:2002PNAS...99.2613S. doi:10.1073/pnas.052707099. PMC 122396. PMID 11867749.
• Oswald F, Kostezka U, Astrahantseff K, et al. (2002). "SHARP is a novel component of the Notch/RBP-Jkappa signalling pathway". EMBO J. 21 (20): 5417–26. doi:10.1093/emboj/cdf549. PMC 129081. PMID 12374742.
• Ariyoshi M, Schwabe JW (2003). "A conserved structural motif reveals the essential transcriptional repression function of Spen proteins and their role in developmental signaling". Genes Dev. 17 (15): 1909–20. doi:10.1101/gad.266203. PMC 196244. PMID 12897056.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Dotzlaw H, Papaioannou M, Moehren U, et al. (2004). "Agonist-antagonist induced coactivator and corepressor interplay on the human androgen receptor". Mol. Cell. Endocrinol. 213 (1): 79–85. doi:10.1016/j.mce.2003.10.036. PMID 15062576. S2CID 46437905.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Vadlamudi RK, Manavathi B, Singh RR, et al. (2005). "An essential role of Pak1 phosphorylation of SHARP in Notch signaling". Oncogene. 24 (28): 4591–6. doi:10.1038/sj.onc.1208672. PMID 15824732.
• Li J, Wang J, Yang X, et al. (2007). "The Spen homolog Msx2-interacting nuclear target protein interacts with the E2 ubiquitin-conjugating enzyme UbcH8". Mol. Cell. Biochem. 288 (1–2): 151–7. doi:10.1007/s11010-006-9131-9. PMID 16583136. S2CID 24935755.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
• Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.
• Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
• Feng Y, Bommer GT, Zhai Y, et al. (2007). "Drosophila split ends homologue SHARP functions as a positive regulator of Wnt/beta-catenin/T-cell factor signaling in neoplastic transformation". Cancer Res. 67 (2): 482–91. doi:10.1158/0008-5472.CAN-06-2314. PMID 17234755.