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SNIP1
Identifiers
Aliases	SNIP1, PMRED, Smad nuclear interacting protein 1, PML1, NEDHCS
External IDs	OMIM: 608241; MGI: 2156003; HomoloGene: 110886; GeneCards: SNIP1; OMA:SNIP1 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	37,554,293 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	124,967,835 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; sural nerve; ; gonad; ; buccal mucosa cell; ; Achilles tendon; ; testicle; ; islet of Langerhans; ; bone marrow cell; ; stromal cell of endometrium; ; white blood cell;
	Top expressed in
	spermatocyte; ; spermatid; ; primitive streak; ; granulocyte; ; epiblast; ; endocardial cushion; ; seminiferous tubule; ; medullary collecting duct; ; medial ganglionic eminence; ; renal corpuscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; mRNA binding; RNA binding;
Cellular component	nucleoplasm; nucleus; cytosol; U2-type precatalytic spliceosome;
Biological process	positive regulation of protein targeting to mitochondrion; I-kappaB kinase/NF-kappaB signaling; gene silencing; regulation of transcription, DNA-templated; production of miRNAs involved in gene silencing by miRNA; mRNA splicing, via spliceosome;
	Sources:Amigo / QuickGO
Orthologs
	79753
	76793
	ENSG00000163877
	ENSMUSG00000050213
	Q8TAD8
	Q8BIZ6
	NM_024700
	NM_175246; NM_001356560
	NP_078976
	NP_780455; NP_001343489
	Wikidata
View/Edit Human	View/Edit Mouse

Smad nuclear-interacting protein 1 is a protein that in humans is encoded by the SNIP1 gene.^[5]^[6]^[7]

Interactions

SNIP1 has been shown to interact with EP300.^[5]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000163877 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000050213 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 Kim RH, Wang D, Tsang M, Martin J, Huff C, de Caestecker MP, Parks WT, Meng X, Lechleider RJ, Wang T, Roberts AB (2000). "A novel smad nuclear interacting protein, SNIP1, suppresses p300-dependent TGF-beta signal transduction". Genes Dev. 14 (13): 1605–16. doi:10.1101/gad.14.13.1605. PMC 316742. PMID 10887155.
↑ Roche KC, Wiechens N, Owen-Hughes T, Perkins ND (2004). "The FHA domain protein SNIP1 is a regulator of the cell cycle and cyclin D1 expression". Oncogene. 23 (50): 8185–8195. doi:10.1038/sj.onc.1208025. PMID 15378006.
↑ "Entrez Gene: SNIP1 Smad nuclear interacting protein 1".

Kim RH, Flanders KC, Birkey Reffey S, Anderson LA, Duckett CS, Perkins ND, Roberts AB (2001). "SNIP1 inhibits NF-kappa B signaling by competing for its binding to the C/H1 domain of CBP/p300 transcriptional co-activators". J. Biol. Chem. 276 (49): 46297–46304. doi:10.1074/jbc.M103819200. PMID 11567019.
Lin Y, Martin J, Gruendler C, Farley J, Meng X, Li BY, Lechleider R, Huff C, Kim RH, Grasser WA, Paralkar V, Wang T (2002). "A novel link between the proteasome pathway and the signal transduction pathway of the bone morphogenetic proteins (BMPs)". BMC Cell Biol. 3: 15. doi:10.1186/1471-2121-3-15. PMC 117437. PMID 12097147.
Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–1332. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
Cui Q, Lim SK, Zhao B, Hoffmann FM (2005). "Selective inhibition of TGF-beta responsive genes by Smad-interacting peptide aptamers from FoxH1, Lef1 and CBP". Oncogene. 24 (24): 3864–3874. doi:10.1038/sj.onc.1208556. PMID 15750622.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–1178. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–648. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
Fujii M, Lyakh LA, Bracken CP, Fukuoka J, Hayakawa M, Tsukiyama T, Soll SJ, Harris M, Rocha S, Roche KC, Tominaga S, Jen J, Perkins ND, Lechleider RJ, Roberts AB (2006). "SNIP1 is a candidate modifier of the transcriptional activity of c-Myc on E box-dependent target genes". Mol. Cell. 24 (5): 771–783. doi:10.1016/j.molcel.2006.11.006. PMID 17157259.

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000163877 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000050213 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10887155-5] 1 2 Kim RH, Wang D, Tsang M, Martin J, Huff C, de Caestecker MP, Parks WT, Meng X, Lechleider RJ, Wang T, Roberts AB (2000). "A novel smad nuclear interacting protein, SNIP1, suppresses p300-dependent TGF-beta signal transduction". Genes Dev. 14 (13): 1605–16. doi:10.1101/gad.14.13.1605. PMC 316742. PMID 10887155.

[pmid15378006-6] Roche KC, Wiechens N, Owen-Hughes T, Perkins ND (2004). "The FHA domain protein SNIP1 is a regulator of the cell cycle and cyclin D1 expression". Oncogene. 23 (50): 8185–8195. doi:10.1038/sj.onc.1208025. PMID 15378006.

[entrez-7] "Entrez Gene: SNIP1 Smad nuclear interacting protein 1".

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Interactions

References

Further reading