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MFSD3
Identifiers
Aliases	MFSD3, major facilitator superfamily domain containing 3
External IDs	MGI: 1916822; GeneCards: MFSD3
Gene location (Human)
Chr.	Chromosome 8 (human)
End	144,511,213 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	76,588,439 bp
RNA expression pattern
	Top expressed in
	mucosa of transverse colon; ; apex of heart; ; right lobe of liver; ; right frontal lobe; ; right lobe of thyroid gland; ; right hemisphere of cerebellum; ; left lobe of thyroid gland; ; right adrenal cortex; ; Brodmann area 9; ; cingulate gyrus;
	Top expressed in
	left lobe of liver; ; masseter muscle; ; quadriceps femoris muscle; ; muscle of thigh; ; vastus lateralis muscle; ; skeletal muscle tissue; ; proximal tubule; ; medial head of gastrocnemius muscle; ; soleus muscle; ; tibialis anterior muscle;
	More reference expression data
	n/a
Gene ontology
Molecular function	solute:proton symporter activity;
Cellular component	integral component of membrane; membrane; integral component of plasma membrane;
Biological process	transmembrane transport; proton transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	113655
	69572
	ENSG00000167700
	ENSMUSG00000019080
	Q96ES6
	Q5U419
	NM_138431
	NM_027122
	NP_612440
	NP_081398
	Wikidata
View/Edit Human	View/Edit Mouse

Solute carrier family 33 member 2 is a protein that in humans is encoded by the SLC33A2 gene. It was previously designated major facilitator superfamily domain containing 3 (MFSD3). It belongs to the major facilitator superfamily (MFS) Pfam clan.^[5]^[6] It is an Atypical solute carrier located to the neuronal plasma membrane.^[7]

HGNC:25157

TCDB: 2.A.1.25.4

MFSD3 belongs to AMTF15.^[8]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000167700 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000019080 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Perland E, Fredriksson R (March 2017). "Classification Systems of Secondary Active Transporters". Trends in Pharmacological Sciences. 38 (3): 305–315. doi:10.1016/j.tips.2016.11.008. PMID 27939446.
↑ Finn RD, Coggill P, Eberhardt RY, Eddy SR, Mistry J, Mitchell AL, et al. (January 2016). "The Pfam protein families database: towards a more sustainable future". Nucleic Acids Research. 44 (D1): D279–85. doi:10.1093/nar/gkv1344. PMC 4702930. PMID 26673716.
↑ Perland E, Hellsten SV, Lekholm E, Eriksson MM, Arapi V, Fredriksson R (February 2017). "The Novel Membrane-Bound Proteins MFSD1 and MFSD3 are Putative SLC Transporters Affected by Altered Nutrient Intake". Journal of Molecular Neuroscience. 61 (2): 199–214. doi:10.1007/s12031-016-0867-8. PMC 5321710. PMID 27981419.
↑ Perland E, Bagchi S, Klaesson A, Fredriksson R (September 2017). "Characteristics of 29 novel atypical solute carriers of major facilitator superfamily type: evolutionary conservation, predicted structure and neuronal co-expression". Open Biology. 7 (9) 170142. doi:10.1098/rsob.170142. PMC 5627054. PMID 28878041.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000167700 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000019080 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Perland E, Fredriksson R (March 2017). "Classification Systems of Secondary Active Transporters". Trends in Pharmacological Sciences. 38 (3): 305–315. doi:10.1016/j.tips.2016.11.008. PMID 27939446.

[6] Finn RD, Coggill P, Eberhardt RY, Eddy SR, Mistry J, Mitchell AL, et al. (January 2016). "The Pfam protein families database: towards a more sustainable future". Nucleic Acids Research. 44 (D1): D279–85. doi:10.1093/nar/gkv1344. PMC 4702930. PMID 26673716.

[7] Perland E, Hellsten SV, Lekholm E, Eriksson MM, Arapi V, Fredriksson R (February 2017). "The Novel Membrane-Bound Proteins MFSD1 and MFSD3 are Putative SLC Transporters Affected by Altered Nutrient Intake". Journal of Molecular Neuroscience. 61 (2): 199–214. doi:10.1007/s12031-016-0867-8. PMC 5321710. PMID 27981419.

[8] Perland E, Bagchi S, Klaesson A, Fredriksson R (September 2017). "Characteristics of 29 novel atypical solute carriers of major facilitator superfamily type: evolutionary conservation, predicted structure and neuronal co-expression". Open Biology. 7 (9) 170142. doi:10.1098/rsob.170142. PMC 5627054. PMID 28878041.

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References