SIDT1

SIDT1
Identifiers
Aliases	SIDT1, B830021E24Rik, SID-1, SID1, SID1 transmembrane family member 1
External IDs	OMIM: 606816; MGI: 2443155; GeneCards: SIDT1
Gene location (Human)
Chr.	Chromosome 3 (human)
End	113,629,575 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	44,153,559 bp
RNA expression pattern
	Top expressed in
	right hemisphere of cerebellum; ; rectum; ; mucosa of sigmoid colon; ; granulocyte; ; right frontal lobe; ; tonsil; ; lymph node; ; spleen; ; gallbladder; ; dorsolateral prefrontal cortex;
	Top expressed in
	primary visual cortex; ; superior frontal gyrus; ; lacrimal gland; ; dentate gyrus of hippocampal formation granule cell; ; primary motor cortex; ; parotid gland; ; zygote; ; cerebellar cortex; ; submandibular gland; ; hippocampus proper;
	More reference expression data
	n/a
Gene ontology
Molecular function	RNA transmembrane transporter activity; RNA binding; double-stranded RNA binding;
Cellular component	membrane; integral component of membrane; lysosome; plasma membrane;
Biological process	dsRNA transport; RNA transport;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	54847
	320007
	ENSG00000072858
	ENSMUSG00000022696
	Q9NXL6
	Q6AXF6
NM_001308350; NM_017699; NM_001322294; NM_001322295; NM_001322296;
	NM_001322297; NM_001322298; NM_001322299; NM_001322300
	NM_001159419; NM_198034
NP_001295279; NP_001309223; NP_001309224; NP_001309225; NP_001309226;
	NP_001309227; NP_001309228; NP_001309229; NP_060169
	NP_001152891; NP_932151
	Wikidata
View/Edit Human	View/Edit Mouse

SID1 transmembrane family member 1 is a protein that in humans is encoded by the SIDT1 gene.^[5]

Function

The protein encoded by this gene belongs to SID1 family of transmembrane dsRNA-gated channels. Family members transport dsRNA into cells and are required for systemic RNA interference.

A 2012 study showed that SIDT1 facilitates contact-dependent bidirectional transfer of small RNAs between human cells and that SIDT1-mediated microRNA-21 transfer may contribute to gemcitabine resistance in human adenocarcinoma cells.^[6]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000072858 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000022696 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: SID1 transmembrane family member 1". Retrieved 2017-10-02.
↑ Elhassan MO, Christie J, Duxbury MS (February 2012). "Homo sapiens systemic RNA interference-defective-1 transmembrane family member 1 (SIDT1) protein mediates contact-dependent small RNA transfer and microRNA-21-driven chemoresistance". The Journal of Biological Chemistry. 287 (8): 5267–5277. doi:10.1074/jbc.M111.318865. PMC 3285307. PMID 22174421.

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SIDT1

Function

References

Further reading