// Workers AI · dad joke modeWhat did SH3BP4 say to its date? "You bind well with me.

SH3BP4
Identifiers
Aliases	SH3BP4, BOG25, TTP, SH3 domain binding protein 4
External IDs	OMIM: 605611; MGI: 2138297; HomoloGene: 8726; GeneCards: SH3BP4; OMA:SH3BP4 - orthologs
Gene location (Human) Chr. Chromosome 2 (human) Band 2q37.2 Start 234,952,017 bp End 235,055,714 bp
Gene location (Mouse) Chr. Chromosome 1 (mouse) Band 1|1 D Start 88,998,137 bp End 89,082,790 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in parotid gland trachea mucosa of paranasal sinus renal medulla germinal epithelium nasal epithelium caput epididymis Epithelium of choroid plexus tibia epithelium of lactiferous gland Top expressed in lacrimal gland molar parotid gland maxillary prominence seminal vesicula mandibular prominence ascending aorta vestibular membrane of cochlear duct somite lumbar spinal ganglion More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding identical protein binding GDP-dissociation inhibitor activity Cellular component cytoplasm membrane clathrin-coated pit cytoplasmic vesicle extracellular exosome nucleus clathrin-coated vesicle Biological process cellular response to amino acid stimulus protein localization to lysosome negative regulation of GTPase activity regulation of catalytic activity endocytosis negative regulation of cell growth positive regulation of autophagy amino acid import negative regulation of cell population proliferation negative regulation of TOR signaling Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23677 98402 Ensembl ENSG00000130147 ENSMUSG00000036206 UniProt Q9P0V3 Q921I6 RefSeq (mRNA) NM_014521 NM_133816 RefSeq (protein) NP_055336 NP_001358231 NP_001358232 NP_001358233 NP_001358234 NP_001358235 NP_598577 Location (UCSC) Chr 2: 234.95 – 235.06 Mb Chr 1: 89 – 89.08 Mb PubMed search
Wikidata
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SH3 domain-binding protein 4 is a protein that in humans is encoded by the SH3BP4 gene.

This gene encodes a protein with 3 Asn-Pro-Phe (NPF) motifs, an SH3 domain, a PXXP motif, a bipartite nuclear targeting signal, and a tyrosine phosphorylation site. This protein is involved in cargo-specific control of clathrin-mediated endocytosis, specifically controlling the internalization of a specific protein receptor.

Further reading

• Wong WT, Schumacher C, Salcini AE, et al. (1995). "A protein-binding domain, EH, identified in the receptor tyrosine kinase substrate Eps15 and conserved in evolution". Proc. Natl. Acad. Sci. U.S.A. 92 (21): 9530–4. Bibcode:1995PNAS...92.9530W. doi:10.1073/pnas.92.21.9530. PMC 40835. PMID 7568168.
• Salcini AE, Confalonieri S, Doria M, et al. (1997). "Binding specificity and in vivo targets of the EH domain, a novel protein-protein interaction module". Genes Dev. 11 (17): 2239–49. doi:10.1101/gad.11.17.2239. PMC 275390. PMID 9303539.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID 15324660. S2CID 2371325.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Khanobdee K, Kolberg JB, Dunlevy JR (2005). "Nuclear and plasma membrane localization of SH3BP4 in retinal pigment epithelial cells". Mol. Vis. 10: 933–42. PMID 15616480.
• Benzinger A, Muster N, Koch HB, et al. (2005). "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer". Mol. Cell. Proteomics. 4 (6): 785–95. doi:10.1074/mcp.M500021-MCP200. PMID 15778465.
• Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. Bibcode:2005Natur.434..724H. doi:10.1038/nature03466. PMID 15815621.
• Tosoni D, Puri C, Confalonieri S, et al. (2006). "TTP specifically regulates the internalization of the transferrin receptor". Cell. 123 (5): 875–88. doi:10.1016/j.cell.2005.10.021. PMID 16325581. S2CID 5809800.
• Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.