SERPINB8

SERPINB8
Identifiers
Aliases	SERPINB8, CAP2, PI8, serpin family B member 8, PSS5, PI-8, HMSD, HSMD-v, C18orf53
External IDs	OMIM: 601697; MGI: 894657; HomoloGene: 74445; GeneCards: SERPINB8; OMA:SERPINB8 - orthologs
Gene location (Human)
Chr.	Chromosome 18 (human)
End	64,019,779 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	107,538,214 bp
RNA expression pattern
	Top expressed in
	monocyte; ; skin of leg; ; skin of abdomen; ; granulocyte; ; gallbladder; ; islet of Langerhans; ; gingival epithelium; ; Descending thoracic aorta; ; tibial arteries; ; testicle;
	Top expressed in
	lumbar spinal ganglion; ; esophagus; ; skin of external ear; ; lip; ; skin of back; ; conjunctival fornix; ; skin of abdomen; ; stroma of bone marrow; ; epidermis; ; cervix;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	peptidase inhibitor activity; protein binding; serine-type endopeptidase inhibitor activity;
Cellular component	cytoplasm; cytosol; extracellular exosome; extracellular space; collagen-containing extracellular matrix;
Biological process	negative regulation of peptidase activity; negative regulation of endopeptidase activity; epithelial cell-cell adhesion;
	Sources:Amigo / QuickGO
Orthologs
	5271
	20725
	ENSG00000166401
	ENSMUSG00000026315
	P50452
	O08800
NM_001031848; NM_001276490; NM_002640; NM_198833; NM_001348367;
	NM_001348368; NM_001348369; NM_001348370; NM_001366198
	NM_001159748; NM_011459
NP_001027018; NP_001263419; NP_002631; NP_942130; NP_001335296;
	NP_001335297; NP_001335298; NP_001335299; NP_001353127
	NP_001153220; NP_035589
	Wikidata
View/Edit Human	View/Edit Mouse

Serpin B8 is a protein that in humans is encoded by the SERPINB8 gene.^[5]^[6]^[7]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000166401 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026315 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Sprecher CA, Morgenstern KA, Mathewes S, Dahlen JR, Schrader SK, Foster DC, Kisiel W (Jan 1996). "Molecular cloning, expression, and partial characterization of two novel members of the ovalbumin family of serine proteinase inhibitors". J Biol Chem. 270 (50): 29854–61. doi:10.1074/jbc.270.50.29854. PMID 8530382.
↑ Bartuski AJ, Kamachi Y, Schick C, Overhauser J, Silverman GA (Nov 1997). "Cytoplasmic antiproteinase 2 (PI8) and bomapin (PI10) map to the serpin cluster at 18q21.3". Genomics. 43 (3): 321–8. doi:10.1006/geno.1997.4827. PMID 9268635.
↑ "Entrez Gene: SERPINB8 serpin peptidase inhibitor, clade B (ovalbumin), member 8".

External links

The MEROPS online database for peptidases and their inhibitors: I04.013^{[permanent dead link]}
SERPINB8+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article on a gene on human chromosome 18 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000166401 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026315 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8530382-5] Sprecher CA, Morgenstern KA, Mathewes S, Dahlen JR, Schrader SK, Foster DC, Kisiel W (Jan 1996). "Molecular cloning, expression, and partial characterization of two novel members of the ovalbumin family of serine proteinase inhibitors". J Biol Chem. 270 (50): 29854–61. doi:10.1074/jbc.270.50.29854. PMID 8530382.

[pmid9268635-6] Bartuski AJ, Kamachi Y, Schick C, Overhauser J, Silverman GA (Nov 1997). "Cytoplasmic antiproteinase 2 (PI8) and bomapin (PI10) map to the serpin cluster at 18q21.3". Genomics. 43 (3): 321–8. doi:10.1006/geno.1997.4827. PMID 9268635.

[entrez-7] "Entrez Gene: SERPINB8 serpin peptidase inhibitor, clade B (ovalbumin), member 8".

[1]

[2]

[3]

[4]

[5]

[6]

[7]

v t e Serpins
inhibitory	Alpha 1-antichymotrypsin Alpha-1 antitrypsin Alpha 2-antiplasmin Antithrombin C1-inhibitor CU-2010 and CU-2020 Heparin cofactor II Protein C inhibitor Plasminogen activator inhibitor-1 Plasminogen activator inhibitor-2 Protein Z-related protease inhibitor SERPINA1 SERPINA2 SERPINA3 SERPINA4 SERPINA5 SERPINA9 SERPINA14 SERPINB1 SERPINB2 SERPINB3 SERPINB4 SERPINB5 SERPINB6 SERPINB7 SERPINB8 SERPINB9 SERPINB10 SERPINB13 SERPINC1 SERPIND1 SERPINE1 SERPINE2 SERPINE2 SERPINF1 SERPING1 SERPINH1 SERPINI1 SERPINI2
Cross class inhibitory	MENT SCCA-1 CrmA
noninhibitory	Heat shock protein 47 Maspin Ovalbumin Transcortin Thyroxine-binding globulin Angiotensinogen PEDF
see also disorders of globin and globulin proteins

This page was redesigned at the edge.

A page that knows where it met you.

SERPINB8

See also

References

Further reading

External links