SEMA4G

SEMA4G
Identifiers
Aliases	SEMA4G, semaphorin 4G
External IDs	MGI: 1347047; GeneCards: SEMA4G
Gene location (Human) Chr. Chromosome 10 (human) Band 10q24.31 Start 100,969,518 bp End 100,985,871 bp
Gene location (Mouse) Chr. Chromosome 19 (mouse) Band 19|19 C3 Start 44,989,101 bp End 45,003,397 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of transverse colon rectum right lobe of liver mucosa of ileum right hemisphere of cerebellum body of pancreas right ovary left ovary right lobe of thyroid gland skin of leg Top expressed in left lobe of liver crypt of lieberkuhn of small intestine epithelium of small intestine colon left colon duodenum right lobe of liver jejunum cerebellar cortex ileum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding neuropilin binding semaphorin receptor binding chemorepellent activity Cellular component integral component of membrane plasma membrane membrane extracellular space integral component of plasma membrane Biological process multicellular organism development cell differentiation nervous system development negative chemotaxis neural crest cell migration positive regulation of cell migration negative regulation of axon extension involved in axon guidance semaphorin-plexin signaling pathway Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 57715 26456 Ensembl ENSG00000095539 ENSMUSG00000025207 UniProt Q9NTN9 Q9WUH7 RefSeq (mRNA) NM_001203244 NM_017893 NM_011976 RefSeq (protein) NP_001190173 NP_060363 NP_036106 Location (UCSC) Chr 10: 100.97 – 100.99 Mb Chr 19: 44.99 – 45 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Semaphorin-4G is a protein in humans encoded by the SEMA4G gene.

Semaphorins are a large family of conserved, secreted and membrane associated proteins which possess a semaphoring (Sema) domain and a PSI domain (found in plexins, semaphorins and integrins) in the N-terminal extracellular portion. Semaphorins maintain cell motility and attachment in axon guidance, immune cell maintenance, vascular growth and tumour movement.

Based on sequence and structural similarities, semaphorins are put into eight classes: invertebrates contain classes 1 and 2, viruses have class V, and vertebrates contain classes 3-7. Semaphorins serve as axon guidance ligands via multimeric receptor complexes, some (if not all) containing plexin proteins. This gene encodes a class 4 semaphorin. This gene and the gene for mitochondrial ribosomal protein L43 overlap at map location 10q24.31 and are transcribed in opposite directions.

Further reading

• Pasterkamp RJ, Kolodkin AL (2003). "Semaphorin junction: making tracks toward neural connectivity". Current Opinion in Neurobiology. 13 (1): 79–89. doi:10.1016/S0959-4388(03)00003-5. PMID 12593985. S2CID 40661992.
• Dickson BJ (December 2002). "Molecular mechanisms of axon guidance". Science. 298 (5600). New York, N.Y.: 1959–1964. doi:10.1126/science.1072165. PMID 12471249. S2CID 28328792.
• Holtmaat AJ, De Winter F, De Wit J, Gorter JA, da Silva FH, Verhaagen J (2002). "Semaphorins: Contributors to structural stability of hippocampal networks?". Prog. Brain Res. Plasticity in the Adult Brain: From Genes to Neurotherapy. Vol. 138. pp. 17–38. doi:10.1016/S0079-6123(02)38068-3. ISBN 978-0-444-50981-9. PMID 12432760.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, et al. (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–1178. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Nagase T, Kikuno R, Nakayama M, Hirosawa M, Ohara O (August 2000). "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 7 (4): 273–281. doi:10.1093/dnares/7.4.271. PMID 10997877.