SEMA4B

SEMA4B
Identifiers
Aliases	SEMA4B, SEMAC, SemC, semaphorin 4B
External IDs	OMIM: 617029; MGI: 107559; HomoloGene: 8426; GeneCards: SEMA4B; OMA:SEMA4B - orthologs
Gene location (Human)
Chr.	Chromosome 15 (human)
End	90,229,679 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	79,876,275 bp
RNA expression pattern
	Top expressed in
	mucosa of ileum; ; mucosa of esophagus; ; secondary oocyte; ; muscle layer of sigmoid colon; ; olfactory zone of nasal mucosa; ; gums; ; vagina; ; transverse colon; ; gingival epithelium; ; right lobe of thyroid gland;
	Top expressed in
	cumulus cell; ; external carotid artery; ; submandibular gland; ; ciliary body; ; internal carotid artery; ; lumbar spinal ganglion; ; lip; ; Rostral migratory stream; ; yolk sac; ; blood;
	More reference expression data
	n/a
Gene ontology
Molecular function	neuropilin binding; semaphorin receptor binding; chemorepellent activity;
Cellular component	integral component of membrane; membrane; extracellular space; plasma membrane; integral component of plasma membrane;
Biological process	multicellular organism development; cell differentiation; nervous system development; negative chemotaxis; neural crest cell migration; positive regulation of cell migration; negative regulation of axon extension involved in axon guidance; semaphorin-plexin signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	10509
	20352
	ENSG00000185033
	ENSMUSG00000030539
	Q9NPR2
	Q62179
NM_020210; NM_198925; NM_001324029; NM_001324030; NM_001324031;
	NM_001324032; NM_001324034; NM_001393916
	NM_013659; NM_001360135
NP_001310958; NP_001310959; NP_001310960; NP_001310961; NP_001310962;
	NP_001310963; NP_064595; NP_945119
	NP_038687; NP_001347064
	Wikidata
View/Edit Human	View/Edit Mouse

Semaphorin-4B is a protein that in humans is encoded by the SEMA4B gene.^[5]^[6]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000185033 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000030539 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Puschel AW, Adams RH, Betz H (Jun 1995). "Murine semaphorin D/collapsin is a member of a diverse gene family and creates domains inhibitory for axonal extension". Neuron. 14 (5): 941–8. doi:10.1016/0896-6273(95)90332-1. PMID 7748561.
↑ "Entrez Gene: SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B".

Nagase T, Kikuno R, Hattori A, et al. (2001). "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (6): 347–55. doi:10.1093/dnares/7.6.347. PMID 11214970.
Swiercz JM, Kuner R, Behrens J, Offermanns S (2002). "Plexin-B1 directly interacts with PDZ-RhoGEF/LARG to regulate RhoA and growth cone morphology". Neuron. 35 (1): 51–63. doi:10.1016/S0896-6273(02)00750-X. PMID 12123608.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Liu T, Qian WJ, Gritsenko MA, et al. (2006). "Human Plasma N-Glycoproteome Analysis by Immunoaffinity Subtraction, Hydrazide Chemistry, and Mass Spectrometry". J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMC 1850943. PMID 16335952.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.

This article on a gene on human chromosome 15 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000185033 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000030539 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7748561-5] Puschel AW, Adams RH, Betz H (Jun 1995). "Murine semaphorin D/collapsin is a member of a diverse gene family and creates domains inhibitory for axonal extension". Neuron. 14 (5): 941–8. doi:10.1016/0896-6273(95)90332-1. PMID 7748561.

[entrez-6] "Entrez Gene: SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B".

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SEMA4B

References

Further reading