SEC22B

SEC22B
Identifiers
Aliases	SEC22B, ERS-24, SEC22L1, SEC22 homolog B, vesicle trafficking protein (gene/pseudogene), SEC22 homolog B, vesicle trafficking protein
External IDs	OMIM: 604029; MGI: 1338759; GeneCards: SEC22B
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2NUP, 2NUT, 3EGD, 3EGX
Gene location (Human)
Chr.	Chromosome 1 (human)
End	120,176,520 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	97,830,592 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; body of pancreas; ; islet of Langerhans; ; stromal cell of endometrium; ; anterior pituitary; ; epithelium of colon; ; rectum; ; monocyte; ; left adrenal gland; ; Descending thoracic aorta;
	Top expressed in
	cumulus cell; ; endocardial cushion; ; neural layer of retina; ; yolk sac; ; molar; ; lacrimal gland; ; islet of Langerhans; ; calvaria; ; primitive streak; ; seminal vesicula;
	More reference expression data
	n/a
Gene ontology
Molecular function	SNAP receptor activity; protein binding; syntaxin binding; SNARE binding;
Cellular component	integral component of membrane; Golgi apparatus; endoplasmic reticulum membrane; membrane; melanosome; endoplasmic reticulum; endoplasmic reticulum-Golgi intermediate compartment membrane; endoplasmic reticulum-Golgi intermediate compartment; SNARE complex; Golgi membrane; transport vesicle; phagocytic vesicle membrane; ER to Golgi transport vesicle membrane; synaptic vesicle;
Biological process	positive regulation of protein catabolic process; vesicle fusion with Golgi apparatus; COPII vesicle coating; protein transport; vesicle-mediated transport; exocytosis; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; endoplasmic reticulum to Golgi vesicle-mediated transport; vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane; negative regulation of autophagosome assembly;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	9554
	20333
	ENSG00000265808
	ENSMUSG00000027879
	O75396
	O08547
	NM_004892
	NM_011342
	NP_004883
	NP_035472
	Wikidata
View/Edit Human	View/Edit Mouse

Vesicle-trafficking protein SEC22b is a protein that in humans is encoded by the SEC22B gene.^[5]^[6]^[7]

Function

The protein encoded by this gene is a member of the SEC22 family of vesicle trafficking proteins. It associates with other SNARE proteins to form a SNARE complex and it is thought to play a role in the ER-Golgi protein trafficking. It is required for platelet alpha-granule biogenesis in megakaryocytes^[8] and is essential for the elongated morphology of endothelial cell Weibel-Palade bodies.^[9] This protein has strong similarity to Mus musculus and Cricetulus griseus proteins. There is evidence for use of multiple polyadenylation sites for the transcript.^[7] SEC22B has been shown to interact with syntaxin 18^[10] and syntaxin 5.^[11]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000265808 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000027879 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Hay JC, Chao DS, Kuo CS, Scheller RH (April 1997). "Protein interactions regulating vesicle transport between the endoplasmic reticulum and Golgi apparatus in mammalian cells". Cell. 89 (1): 149–158. doi:10.1016/S0092-8674(00)80191-9. PMID 9094723. S2CID 8682509.
↑ Okumura AJ, Hatsuzawa K, Tamura T, Nagaya H, Saeki K, Okumura F, et al. (February 2006). "Involvement of a novel Q-SNARE, D12, in quality control of the endomembrane system". The Journal of Biological Chemistry. 281 (7): 4495–4506. doi:10.1074/jbc.M509715200. PMID 16354670.
1 2 "Entrez Gene: SEC22B SEC22 vesicle trafficking protein homolog B (S. cerevisiae)".
↑ Lo RW, Li L, Pluthero FG, Leung R, Eto K, Kahr WH (August 2020). "The endoplasmic reticulum protein SEC22B interacts with NBEAL2 and is required for megakaryocyte α-granule biogenesis". Blood. 136 (6): 715–725. doi:10.1182/blood.2019004276. PMID 32384141.
↑ Karampini E, Bürgisser PE, Olins J, Mulder AA, Jost CR, Geerts D, et al. (April 2021). "Sec22b determines Weibel-Palade body length by controlling anterograde ER-Golgi transport". Haematologica. 106 (4): 1138–1147. doi:10.3324/haematol.2019.242727. PMC 8018124. PMID 32336681.
↑ Hatsuzawa K, Hirose H, Tani K, Yamamoto A, Scheller RH, Tagaya M (May 2000). "Syntaxin 18, a SNAP receptor that functions in the endoplasmic reticulum, intermediate compartment, and cis-Golgi vesicle trafficking". The Journal of Biological Chemistry. 275 (18): 13713–13720. doi:10.1074/jbc.275.18.13713. PMID 10788491.
↑ Kat M, Karampini E, Hoogendijk AJ, Bürgisser PE, Mulder AA, Van Alphen FP, et al. (August 2022). "Syntaxin 5 determines Weibel-Palade body size and von Willebrand factor secretion by controlling Golgi architecture". Haematologica. 107 (8): 1827–1839. doi:10.3324/haematol.2021.280121. PMC 9335113. PMID 35081689.

Chi A, Valencia JC, Hu ZZ, Watabe H, Yamaguchi H, Mangini NJ, et al. (November 2006). "Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes". Journal of Proteome Research. 5 (11): 3135–3144. doi:10.1021/pr060363j. PMID 17081065.
Breuza L, Halbeisen R, Jenö P, Otte S, Barlowe C, Hong W, et al. (November 2004). "Proteomics of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membranes from brefeldin A-treated HepG2 cells identifies ERGIC-32, a new cycling protein that interacts with human Erv46". The Journal of Biological Chemistry. 279 (45): 47242–47253. doi:10.1074/jbc.M406644200. PMID 15308636.
Nakajima K, Hirose H, Taniguchi M, Kurashina H, Arasaki K, Nagahama M, et al. (August 2004). "Involvement of BNIP1 in apoptosis and endoplasmic reticulum membrane fusion". The EMBO Journal. 23 (16): 3216–3226. doi:10.1038/sj.emboj.7600333. PMC 514507. PMID 15272311.
Fu GK, Wang JT, Yang J, Au-Young J, Stuve LL (July 2004). "Circular rapid amplification of cDNA ends for high-throughput extension cloning of partial genes". Genomics. 84 (1): 205–210. doi:10.1016/j.ygeno.2004.01.011. PMID 15203218.
Hirose H, Arasaki K, Dohmae N, Takio K, Hatsuzawa K, Nagahama M, et al. (March 2004). "Implication of ZW10 in membrane trafficking between the endoplasmic reticulum and Golgi". The EMBO Journal. 23 (6): 1267–1278. doi:10.1038/sj.emboj.7600135. PMC 381410. PMID 15029241.
Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, et al. (October 2000). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Research. 10 (10): 1546–1560. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
Xu D, Joglekar AP, Williams AL, Hay JC (December 2000). "Subunit structure of a mammalian ER/Golgi SNARE complex". The Journal of Biological Chemistry. 275 (50): 39631–39639. doi:10.1074/jbc.M007684200. PMID 11035026.
Parlati F, McNew JA, Fukuda R, Miller R, Söllner TH, Rothman JE (September 2000). "Topological restriction of SNARE-dependent membrane fusion". Nature. 407 (6801): 194–198. Bibcode:2000Natur.407..194P. doi:10.1038/35025076. PMID 11001058. S2CID 4410803.
Mao M, Fu G, Wu JS, Zhang QH, Zhou J, Kan LX, et al. (July 1998). "Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning". Proceedings of the National Academy of Sciences of the United States of America. 95 (14): 8175–8180. Bibcode:1998PNAS...95.8175M. doi:10.1073/pnas.95.14.8175. PMC 20949. PMID 9653160.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000265808 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000027879 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[Hay_1997-5] Hay JC, Chao DS, Kuo CS, Scheller RH (April 1997). "Protein interactions regulating vesicle transport between the endoplasmic reticulum and Golgi apparatus in mammalian cells". Cell. 89 (1): 149–158. doi:10.1016/S0092-8674(00)80191-9. PMID 9094723. S2CID 8682509.

[Okumura_2006-6] Okumura AJ, Hatsuzawa K, Tamura T, Nagaya H, Saeki K, Okumura F, et al. (February 2006). "Involvement of a novel Q-SNARE, D12, in quality control of the endomembrane system". The Journal of Biological Chemistry. 281 (7): 4495–4506. doi:10.1074/jbc.M509715200. PMID 16354670.

[entrez-7] 1 2 "Entrez Gene: SEC22B SEC22 vesicle trafficking protein homolog B (S. cerevisiae)".

[8] Lo RW, Li L, Pluthero FG, Leung R, Eto K, Kahr WH (August 2020). "The endoplasmic reticulum protein SEC22B interacts with NBEAL2 and is required for megakaryocyte α-granule biogenesis". Blood. 136 (6): 715–725. doi:10.1182/blood.2019004276. PMID 32384141.

[9] Karampini E, Bürgisser PE, Olins J, Mulder AA, Jost CR, Geerts D, et al. (April 2021). "Sec22b determines Weibel-Palade body length by controlling anterograde ER-Golgi transport". Haematologica. 106 (4): 1138–1147. doi:10.3324/haematol.2019.242727. PMC 8018124. PMID 32336681.

[10] Hatsuzawa K, Hirose H, Tani K, Yamamoto A, Scheller RH, Tagaya M (May 2000). "Syntaxin 18, a SNAP receptor that functions in the endoplasmic reticulum, intermediate compartment, and cis-Golgi vesicle trafficking". The Journal of Biological Chemistry. 275 (18): 13713–13720. doi:10.1074/jbc.275.18.13713. PMID 10788491.

[11] Kat M, Karampini E, Hoogendijk AJ, Bürgisser PE, Mulder AA, Van Alphen FP, et al. (August 2022). "Syntaxin 5 determines Weibel-Palade body size and von Willebrand factor secretion by controlling Golgi architecture". Haematologica. 107 (8): 1827–1839. doi:10.3324/haematol.2021.280121. PMC 9335113. PMID 35081689.

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SEC22B

Function

References

Further reading