SCG3

SCG3
Identifiers
Aliases	SCG3, SGIII, secretogranin III
External IDs	OMIM: 611796; MGI: 103032; HomoloGene: 7526; GeneCards: SCG3; OMA:SCG3 - orthologs
Gene location (Human) Chr. Chromosome 15 (human) Band 15q21.2 Start 51,681,492 bp End 51,721,026 bp
Gene location (Mouse) Chr. Chromosome 9 (mouse) Band 9 D|9 42.32 cM Start 75,550,471 bp End 75,591,338 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in islet of Langerhans beta cell dorsolateral prefrontal cortex right frontal lobe Brodmann area 9 anterior cingulate cortex prefrontal cortex ganglionic eminence amygdala caudate nucleus Top expressed in deep cerebellar nuclei islet of Langerhans pontine nuclei medial vestibular nucleus dorsal tegmental nucleus cerebellar vermis arcuate nucleus paraventricular nucleus of hypothalamus dorsomedial hypothalamic nucleus lobe of cerebellum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function RNA binding Cellular component extracellular region secretory granule lumen transport vesicle membrane membrane cytoplasmic vesicle endoplasmic reticulum lumen secretory granule membrane transport vesicle Biological process platelet degranulation post-translational protein modification protein localization to secretory granule Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 29106 20255 Ensembl ENSG00000104112 ENSMUSG00000032181 UniProt Q8WXD2 P47867 RefSeq (mRNA) NM_013243 NM_001165257 NM_001164790 NM_009130 RefSeq (protein) NP_001158729 NP_037375 NP_001158262 NP_033156 Location (UCSC) Chr 15: 51.68 – 51.72 Mb Chr 9: 75.55 – 75.59 Mb PubMed search
Wikidata
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Secretogranin III, also known as SCG3, is a protein which in humans is encoded by the SCG3 gene.

Function

The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. Granins may serve as precursors for biologically active peptides. Some granins have been shown to function as helper proteins in sorting and proteolytic processing of prohormones; however, the function of this protein is unknown.

Further reading

• Huttner WB, Gerdes HH, Rosa P (January 1991). "The granin (chromogranin/secretogranin) family". Trends in Biochemical Sciences. 16 (1): 27–30. doi:10.1016/0968-0004(91)90012-K. PMID 2053134.
• Ozawa H, Takata K (December 1995). "The granin family--its role in sorting and secretory granule formation". Cell Structure and Function. 20 (6): 415–20. doi:10.1247/csf.20.415. PMID 8825061.
• Dopazo A, Lovenberg TW, Danielson PE, Ottiger HP, Sutcliffe JG (1994). "Primary structure of mouse secretogranin III and its absence from deficient mice". Journal of Molecular Neuroscience. 4 (4): 225–33. doi:10.1007/BF02821554. PMID 7917832. S2CID 6030810.
• Holthuis JC, Jansen EJ, Martens GJ (July 1996). "Secretogranin III is a sulfated protein undergoing proteolytic processing in the regulated secretory pathway". The Journal of Biological Chemistry. 271 (30): 17755–60. doi:10.1074/jbc.271.30.17755. hdl:2066/29535. PMID 8663421.
• Rong YP, Liu F, Zeng LC, Ma WJ, Wei DZ, Han ZG (July 2002). "Cloning and characterization of a novel human secretory protein: secretogranin III". Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao Acta Biochimica et Biophysica Sinica. 34 (4): 411–7. PMID 12098761.
• Hosaka M, Watanabe T, Sakai Y, Uchiyama Y, Takeuchi T (October 2002). "Identification of a chromogranin A domain that mediates binding to secretogranin III and targeting to secretory granules in pituitary cells and pancreatic beta-cells". Molecular Biology of the Cell. 13 (10): 3388–99. doi:10.1091/mbc.02-03-0040. PMC 129953. PMID 12388744.
• Sakai Y, Hosaka M, Hira Y, Harumi T, Ohsawa Y, Wang H, Takeuchi T, Uchiyama Y, Watanabe T (February 2003). "Immunocytochemical localization of secretogranin III in the anterior lobe of male rat pituitary glands". The Journal of Histochemistry and Cytochemistry. 51 (2): 227–38. doi:10.1177/002215540305100211. PMID 12533531.
• Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A (October 2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Research. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Hosaka M, Suda M, Sakai Y, Izumi T, Watanabe T, Takeuchi T (January 2004). "Secretogranin III binds to cholesterol in the secretory granule membrane as an adapter for chromogranin A". The Journal of Biological Chemistry. 279 (5): 3627–34. doi:10.1074/jbc.M310104200. PMID 14597614.
• Sakai Y, Hosaka M, Yoshinaga A, Hira Y, Harumi T, Watanabe T (March 2004). "Immunocytochemical localization of secretogranin III in the endocrine pancreas of male rats". Archives of Histology and Cytology. 67 (1): 57–64. doi:10.1679/aohc.67.57. PMID 15125023.
• Otsuki T, Ota T, Nishikawa T, Hayashi K, Suzuki Y, Yamamoto J, Wakamatsu A, Kimura K, Sakamoto K, Hatano N, Kawai Y, Ishii S, Saito K, Kojima S, Sugiyama T, Ono T, Okano K, Yoshikawa Y, Aotsuka S, Sasaki N, Hattori A, Okumura K, Nagai K, Sugano S, Isogai T (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Research. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
• Tanabe A, Yanagiya T, Iida A, Saito S, Sekine A, Takahashi A, Nakamura T, Tsunoda T, Kamohara S, Nakata Y, Kotani K, Komatsu R, Itoh N, Mineo I, Wada J, Funahashi T, Miyazaki S, Tokunaga K, Hamaguchi K, Shimada T, Tanaka K, Yamada K, Hanafusa T, Oikawa S, Yoshimatsu H, Sakata T, Matsuzawa Y, Kamatani N, Nakamura Y, Hotta K (March 2007). "Functional single-nucleotide polymorphisms in the secretogranin III (SCG3) gene that form secretory granules with appetite-related neuropeptides are associated with obesity". The Journal of Clinical Endocrinology and Metabolism. 92 (3): 1145–54. doi:10.1210/jc.2006-1808. PMID 17200173.