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From Wikipedia, the free encyclopedia
Raymond Y. Chang
M.D., FACP
Born1957 (age 68–69)
Alma materBrown University
Warren Alpert Medical School
Known forIntegrative oncology, Drug repurposing in cancer treatment
Scientific career
FieldsInternal medicine, Integrative oncology
InstitutionsMemorial Sloan Kettering Cancer Center
Weill Cornell Medical College
NewYork–Presbyterian Hospital
Websitewww.meridianmedical.org

Raymond Chang (born 1957), is an American physician specializing in integrative oncology. His research examines the use of Chinese herbs and repurposing of common drugs for cancer treatment and the integration of Western and Eastern medical practices.

Early life and education

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Chang was born in Hong Kong and later moved to the United States. He earned a Bachelor of Arts degree, magna cum laude, from Brown University, where he was elected to Phi Beta Kappa and Sigma Xi.[1] He received his Doctor of Medicine from the Warren Alpert Medical School of Brown University.[2] He completed his residency at Waterbury Hospital, affiliated with Yale University, and was a Kaiser Fellow at NewYork–Presbyterian Hospital/Weill Cornell Medical Center.[3]

Career

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From 1987 to 1997, Chang was affiliated with Memorial Sloan Kettering Cancer Center.[3] He served on the faculty of Weill Cornell Medical College from 1987 to 2014 and as an attending physician at NewYork–Presbyterian Hospital from 1997 to 2014.[1]

In 1997, Chang founded the Institute of East–West Medicine, a non-profit organization focused on integration of Western medicine and Asian healing traditions.[2][4] He later established the Meridian Medical Group in New York City, which provides combined conventional and alternative treatments.[5] In 2001, Chang chaired the First International Conference on Asian Therapies for Cancer in New York.[6]

Chang has been a member of the American Society of Clinical Oncology,[7][8] the European Society for Medical Oncology, the Royal Society of Medicine, the European Society for Hyperthermic Oncology, and the American Society of Medical Acupuncture.[9][3] He has served on editorial boards of Complementary and Alternative Medicine and Integrative Cancer Therapies, and on advisory boards for the National Cancer Institute's PDQ database and the Continuum Center for Health and Healing at Beth Israel Hospital in New York.[10]

Research contributions

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Chang has authored over 70 academic papers with over 1000 citations.[11] His research examines combination treatment strategies and drug repurposing for cancer and COVID-19, the integration of Eastern and Western medicine in oncology and immunology, the use of medicinal mushrooms and Chinese herbs in oncology, and the use of acupuncture in infertility.[12] Since 2004, he collaborated with Dr. Thomas Nesselhut and Professor Fred Fändrich and published on dendritic cell vaccine research for cancer.[13][14][15][16][17][18]

He has proposed a "cocktail approach" to cancer treatment in 2008, advocating the use of multiple therapeutic agents and modalities simultaneously in combination, which he outlined in his 2011 book Beyond the Magic Bullet: The Anti-Cancer Cocktail.[19] As part of a cocktail approach would be the use of repurposed drugs and Chang suggested that anti-parasitics such as anti-malarials could be a source of anti-cancer drugs.[20] He also reviewed the use of Chinese herbs with chemotherapy for cancer[21] and the use of metformin as an anticancer treatment.

Chang is a licensed acupuncturist and published on acupuncture in reproductive medicine, including its application during in vitro fertilization (IVF).[22][23][24][25][26] A 2003 review in Fertility and Sterility summarized possible effects of acupuncture on uterine blood flow, hormone regulation, and stress reduction.[27]

In 2022, Chang co-authored studies on the repositioning of chloroquine and hydroxychloroquine as potential prophylactic agents against SARS-CoV-2 and was one of the first to advocate the use of lactoferrin for COVID-19.[28][29][30][31] He has also examined bioactive polysaccharides from traditional Chinese medicine herbs, including medicinal mushrooms, for their immunological effects.[32][33][34][35][36]

He has evaluated natural products such as mangosteen and soursop, noting that most evidence is limited to in vitro studies without established efficacy in humans.[37]

Selected publications

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Books

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Chang also authored a chapter on integrative oncology in the textbook Integrative Medicine: Principles for Practice, edited by Benjamin Kligler and Roberta Lee.[43]

Media

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In 1999, New York Magazine profiled Chang as one of New York City's "New Healers," describing his integrative approaches to cancer and fertility treatment.[44] He appeared as a commenting physician in the 2015 documentary Surviving Terminal Cancer, discussing the "cocktail approach" to cancer treatment.[45]

Chang has been interviewed by Acupuncture Today[2] and appeared on The Moss Report Podcast in 2021, discussing integrative oncology and drug repurposing.[46] In 2023, he was featured in Kaurspace Magazine regarding alternative cancer therapies.[47]

References

[edit]
  1. 1 2 "Raymond Chang MD FACP". Meridian Medical Group - "Where you have options". 2014-05-09. Retrieved 2025-08-22.
  2. 1 2 3 Waters, Jennifer. "An Interview With Raymond Chang, MD | Acupuncture Today". acupuncturetoday.com. Retrieved 2025-08-22.
  3. 1 2 3 "ORCID". orcid.org. Retrieved 2025-08-22.
  4. ↑ "Meridian Medical Group". healnavigator.com. Retrieved 2025-08-22.
  5. ↑ "About Us - Meridian Medical Group". 2021-08-21. Retrieved 2025-08-22.
  6. ↑ Chang, Raymond; White, Jeffrey D. (October 2002). "Asian Therapies for Cancer—Coming of Age". The Journal of Alternative and Complementary Medicine. 8 (5): 541–543. doi:10.1089/107555302320825039. ISSN 1075-5535. PMID 12470433.
  7. ↑ "ASCO Publications". American Society of Clinical Oncology. Retrieved 2025-08-22.
  8. ↑ "ASCO Meeting Program Guide". meetings.asco.org. Retrieved 2025-08-22.
  9. ↑ "Dr. Raymond Chang, MD". Doximity. Retrieved 2025-08-22.
  10. ↑ "Continuum Center for Health and Healing - SourceWatch". www.sourcewatch.org. Retrieved 2025-08-23.
  11. ↑ "Raymond Y. Chang". scholar.google.com. Retrieved 2025-08-23.
  12. ↑ Chang, Raymond (2022-06-01), "Repurposing of Metformin as a Multifaceted and Multitasking Preventative and Treatment for Cancer", in K. Saxena, Shailendra (ed.), Drug Repurposing - Molecular Aspects and Therapeutic Applications, IntechOpen, doi:10.5772/intechopen.96101, ISBN 978-1-83969-957-3, retrieved 2025-08-31
  13. ↑ Nesselhut, J.; Marx, D.; Lorenzen, D.; Cillien, N.; Goebel, W.; Chang, R. Y.; Brockmann, W.; Peters, J. H.; Nesselhut, K.; Fändrich, F.; Nesselhut, T. (2011-05-20). "Improvement of dendritic cell therapy in glioblastoma multiforme WHO 4 by Newcastle disease virus". Journal of Clinical Oncology. 29 (15_suppl): 2508. doi:10.1200/jco.2011.29.15_suppl.2508. ISSN 0732-183X.
  14. ↑ "5 Countries Developing Cell Therapy". CNN Indonesia. Retrieved 2025-08-22.
  15. ↑ Nesselhut, J.; Marx, D.; Chang, R. Y.; Lorenzen, D.; Cillien, N.; Goebel, W.; Fändrich, F.; Nesselhut, T. (2010-05-20). "Immunotherapy with dendritic cells as a second-line therapy in advanced pleural mesothelioma". Journal of Clinical Oncology. 28 (15_suppl) e13063. doi:10.1200/jco.2010.28.15_suppl.e13063. ISSN 0732-183X.
  16. ↑ Nesselhut, Jan; Marx, Dagmar; Chang, Raymond Y.; Nesselhut, Thomas (2018-05-20). "Dendritic cell based immunotherapy in metastatic uveal melanoma". Journal of Clinical Oncology. 36 (15_suppl) e21526. doi:10.1200/JCO.2018.36.15_suppl.e21526. ISSN 0732-183X.
  17. ↑ "Improvement of dendritic cell therapy in glioblastoma multiforme WHO 4 by Newcastle disease virus". IOZK. 2011-06-06. Retrieved 2025-08-22.
  18. ↑ Nesselhut, T.; Chang, R. Y.; Matthes, C.; Marx, D.; Lorenzen, D. R.; Cillien, N.; Martin, M.; Gorter, R.; Peters, J. H. (2004-07-15). "Cancer therapy with unloaded monocyte-derived dendritic cells in patients with inoperable pancreatic and gall bladder cancer". Journal of Clinical Oncology. 22 (14_suppl): 2569. doi:10.1200/jco.2004.22.90140.2569. ISSN 0732-183X.
  19. ↑ FACP, Raymond Chang MD (2008-10-26). "Off-label Drugs and its potential use against cancer – An Intro by Raymond Chang MD". Off-label Cancer Treatments. Retrieved 2025-08-31.
  20. ↑ Duffy, Robert; Wade, Christine; Chang, Raymond (2012-09-01). "Discovery of anticancer drugs from antimalarial natural products: a MEDLINE literature review". Drug Discovery Today. 17 (17–18): 942–953. doi:10.1016/j.drudis.2012.03.013. ISSN 1359-6446. PMID 22504324.
  21. ↑ McCulloch, Michael; Ly, Helen; Broffman, Michael; See, Caylie; Clemons, Jen; Chang, Raymond (2016-09-01). "Chinese Herbal Medicine and Fluorouracil-Based Chemotherapy for Colorectal Cancer: A Quality-Adjusted Meta-Analysis of Randomized Controlled Trials". Integrative Cancer Therapies. 15 (3): 285–307. doi:10.1177/1534735416638738. ISSN 1534-7354. PMC 5739191. PMID 27151587.
  22. ↑ Donaldson-Evans, Catherine (2015-03-25). "Acupuncture: A Cure for Infertility?". Fox News. Retrieved 2025-08-22.
  23. ↑ "Acupuncture for fertility: Doctors say, 'Why not?'". Los Angeles Times. 2005-07-04. Retrieved 2025-08-22.
  24. ↑ "Increase Your Fertility with Acupuncture". www.yorktraditionalacupuncture.co.uk. Retrieved 2025-08-22.
  25. ↑ "Infertility Treatment". bayareaihc. Retrieved 2025-08-23.
  26. ↑ "How Acupuncture Enhances Fertility". The Yinova Center. Retrieved 2025-08-23.
  27. ↑ Robinson, Kathleen (April 29, 2003). "Acupuncture has numerous potential fertility-boosting benefits according to New York Weill Cornell physician-scientists". Cornell Chronicle.
  28. ↑ Chang, Raymond; Sun, Wei-Zen (October 2020). "Repositioning chloroquine as antiviral prophylaxis against COVID-19: potential and challenges". Drug Discovery Today. 25 (10): 1786–1792. doi:10.1016/j.drudis.2020.06.030. ISSN 1878-5832. PMC 7831558. PMID 32629169.
  29. ↑ "Researchers looking into lactoferrin 'pink gold' as potential COVID-19 treatment". 9now.nine.com.au. Retrieved 2025-08-23.
  30. ↑ https://www.senatenj.com/ArchiveCenter/ViewFile/Item/1625
  31. ↑ Chang, Raymond; Sun, Wei-Zen (17 March 2020). "Repositioning Chloroquine as Ideal Antiviral Prophylactic against COVID-19 - Time is Now". Preprints.org. doi:10.20944/preprints202003.0279.v1. Archived from the original on 2025-02-15.
  32. ↑ "Alternative Treatment for Cancer (383 Pages)". Annals of Traditional chinese Medicine – vol. 3. doi:10.1142/9789812709301_fmatter. Retrieved 31 August 2025.
  33. ↑ Chang, Raymond; Sun, Wei-Zen (2020-10-01). "Repositioning chloroquine as antiviral prophylaxis against COVID-19: potential and challenges". Drug Discovery Today. 25 (10): 1786–1792. doi:10.1016/j.drudis.2020.06.030. ISSN 1359-6446. PMC 7831558. PMID 32629169.
  34. ↑ Raymond Y., Chang. "Bioactive Polysaccharides from TCM Herbs as Anti-Cancer Adjuvants" (PDF). Retrieved 23 August 2025.
  35. ↑ "Functional Properties of Edible Mushrooms – Dr. Raymond Chang - Meridian Medical Group". 2021-07-30. Retrieved 2025-08-22.
  36. ↑ Chang, R. (1996). "Functional properties of edible mushrooms". Nutrition Reviews. 54 (11 Pt 2): S91–93. doi:10.1111/j.1753-4887.1996.tb03825.x. ISSN 0029-6643. PMID 9110582.
  37. ↑ "Scientists say there is insufficient evidence to prove mangosteen, soursop and coconut water work as natural health cures". Fact Check. Archived from the original on 2025-02-11. Retrieved 2025-08-23.
  38. ↑ 張毅生 (1996). 醫藥真言 (in Chinese). 民生報出版. ISBN 978-957-8932-67-8.
  39. ↑ Chang, Raymond; Oumano, Elena (3 January 2007). What Your Doctor May Not Tell You About(TM) Getting Pregnant: Boost Your Fertility with the Best of Traditional and Alternative Therapies. Grand Central Publishing. ISBN 978-0-446-69496-4. OL 7538515M.
  40. ↑ "Beyond the Magic Bullet: The Anti-Cancer Cocktail by Raymond Chang". www.publishersweekly.com. Retrieved 2025-08-22.
  41. ↑ "Shelf Awareness for Thursday, March 22, 2012". www.shelf-awareness.com. Retrieved 2025-08-22.
  42. ↑ Chang, Raymond (2012). Beyond the Magic Bullet: The Anti-Cancer Cocktail. Square One Publishers. ISBN 978-0-7570-0232-8.
  43. ↑ Integrative Medicine: Principles for Practice. ISBN 978-0-07-140239-2.
  44. ↑ "The New Healers". New York Magazine. 1999-04-05. Retrieved 2025-08-23.
  45. ↑ Hope, Justus R. (2025-06-21). "Ivermectin is AI's #1 Drug Against Terminal Cancer". Repurposed Drugs: Powers & Possibilities. Retrieved 2025-08-31.
  46. ↑ "Repurposed Drugs for Cancer with Raymond Chang, M.D." The Moss Report. Ralph W. Moss, Ph.D. 2021. Retrieved 23 August 2025.
  47. ↑ "SICKNESS AND WELLNESS". kaur. space: news + community focused on working differently. 2019-05-02. Retrieved 2025-08-23.
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