RREB1

RREB1
Identifiers
Aliases	RREB1, FINB, HNT, LZ321, RREB-1, Zep-1, ras responsive element binding protein 1
External IDs	OMIM: 602209; MGI: 2443664; HomoloGene: 2218; GeneCards: RREB1; OMA:RREB1 - orthologs
Gene location (Human) Chr. Chromosome 6 (human) Band 6p24.3 Start 7,107,597 bp End 7,251,980 bp
Gene location (Mouse) Chr. Chromosome 13 (mouse) Band 13|13 A3.3 Start 37,962,376 bp End 38,135,981 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in buccal mucosa cell epithelium of nasopharynx oral cavity skin of thigh sural nerve mucosa of pharynx parotid gland skin of hip epithelium of esophagus mucosa of sigmoid colon Top expressed in left lung lobe substantia nigra pineal gland ciliary body lacrimal gland Paneth cell migratory enteric neural crest cell conjunctival fornix anterior amygdaloid area olfactory tubercle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding metal ion binding nucleic acid binding RNA polymerase II core promoter sequence-specific DNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor activity RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nuclear body extracellular exosome fibrillar center nucleus cytoplasm nuclear speck Biological process positive regulation of mammary gland epithelial cell proliferation positive regulation of lamellipodium morphogenesis regulation of transcription, DNA-templated positive regulation of epithelial cell migration transcription by RNA polymerase II transcription, DNA-templated multicellular organism development positive regulation of transcription, DNA-templated positive regulation of substrate adhesion-dependent cell spreading Ras protein signal transduction negative regulation of transcription, DNA-templated positive regulation of wound healing, spreading of epidermal cells negative regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6239 68750 Ensembl ENSG00000124782 ENSMUSG00000039087 UniProt Q92766 Q3UH06 RefSeq (mRNA) NM_001003698 NM_001003699 NM_001003700 NM_001168344 NM_002955 NM_001013392 NM_001039188 NM_001177868 NM_001177869 NM_026830 RefSeq (protein) NP_001003698 NP_001003699 NP_001003700 NP_001161816 NP_001003698.1 NP_001161816.1 NP_001034277 NP_001171339 NP_001171340 NP_081106 NP_001391686 NP_001391687 NP_001391688 NP_001391689 Location (UCSC) Chr 6: 7.11 – 7.25 Mb Chr 13: 37.96 – 38.14 Mb PubMed search
Wikidata
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Ras-responsive element-binding protein 1 is a protein that in humans is encoded by the RREB1 gene.

Clinical significance

Mutations in RREB1 are associated to type 2 diabetes associated end-stage kidney disease.

Further reading

• Thiagalingam A, De Bustros A, Borges M, Jasti R, Compton D, Diamond L, Mabry M, Ball DW, Baylin SB (1996). "RREB-1, a novel zinc finger protein, is involved in the differentiation response to Ras in human medullary thyroid carcinomas". Mol. Cell. Biol. 16 (10): 5335–45. doi:10.1128/mcb.16.10.5335. PMC 231532. PMID 8816445.
• Fujimoto-Nishiyama A, Ishii S, Matsuda S, Inoue JI, Yamamoto T (1997). "A novel zinc finger protein, Finb, is a transcriptional activator and localized in nuclear bodies". Gene. 195 (2): 267–275. doi:10.1016/S0378-1119(97)00172-8. PMID 9305772.
• Zhang L, Zhao J, Edenberg HJ (1999). "A human Raf-responsive zinc-finger protein that binds to divergent sequences". Nucleic Acids Res. 27 (14): 2947–2956. doi:10.1093/nar/27.14.2947. PMC 148511. PMID 10390538.
• Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ray SK, Nishitani J, Petry MW, Fessing MY, Leiter AB (2003). "Novel transcriptional potentiation of BETA2/NeuroD on the secretin gene promoter by the DNA-binding protein Finb/RREB-1". Mol. Cell. Biol. 23 (1): 259–271. doi:10.1128/MCB.23.1.259-271.2003. PMC 140679. PMID 12482979.
• Zhang S, Qian X, Redman C, Bliskovski V, Ramsay ES, Lowy DR, Mock BA (2003). "p16 INK4a gene promoter variation and differential binding of a repressor, the ras-responsive zinc-finger transcription factor, RREB". Oncogene. 22 (15): 2285–2295. doi:10.1038/sj.onc.1206257. PMID 12700664. S2CID 917155.
• Shi Y, Sawada J, Sui G, Affar EB, Whetstine JR, Lan F, Ogawa H, Po-Shan Luke M, Nakatani Y (2003). "Coordinated histone modifications mediated by a CtBP co-repressor complex". Nature. 422 (6933): 735–738. Bibcode:2003Natur.422..735S. doi:10.1038/nature01550. PMID 12700765. S2CID 2670859.
• Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
• Date S, Nibu Y, Yanai K, Hirata J, Yagami K, Fukamizu A (2005). "Finb, a multiple zinc finger protein, represses transcription of the human angiotensinogen gene". Int. J. Mol. Med. 13 (5): 637–42. doi:10.3892/ijmm.13.5.637. PMID 15067362.
• Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–12135. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.