ROCK2

ROCK2
Identifiers
Aliases	ROCK2, ROCK-II, Rho associated coiled-coil containing protein kinase 2
External IDs	OMIM: 604002; MGI: 107926; HomoloGene: 21010; GeneCards: ROCK2; OMA:ROCK2 - orthologs
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4L6Q, 4WOT
Enzyme activity EC # BRENDA ExPASy KEGG MetaCyc 2.7.11.39 ↗ ↗ ↗ ↗
Gene location (Human) Chr. Chromosome 2 (human) Band 2p25.1 Start 11,179,759 bp End 11,348,330 bp
Gene location (Mouse) Chr. Chromosome 12 (mouse) Band 12|12 A1.1 Start 16,894,895 bp End 16,987,823 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon epithelium of colon middle temporal gyrus thoracic diaphragm biceps brachii superficial temporal artery Skeletal muscle tissue of biceps brachii Brodmann area 10 cerebellar vermis Brodmann area 46 Top expressed in tail of embryo aortic valve ascending aorta muscle of thigh dentate gyrus of hippocampal formation granule cell genital tubercle superior frontal gyrus triceps brachii muscle primary visual cortex thoracic diaphragm More reference expression data BioGPS n/a
Gene ontology Molecular function transferase activity nucleotide binding protein kinase activity structural molecule activity metal ion binding kinase activity protein serine/threonine kinase activity protein binding ATP binding Rho-dependent protein serine/threonine kinase activity RNA binding tau protein binding tau-protein kinase activity Cellular component cytoplasm centrosome membrane plasma membrane microtubule organizing center cytoplasmic ribonucleoprotein granule cytoskeleton nucleus cytosol intracellular anatomical structure Biological process smooth muscle contraction positive regulation of protein phosphorylation intracellular signal transduction regulation of actin cytoskeleton organization centrosome duplication phosphorylation rhythmic process ephrin receptor signaling pathway cellular response to testosterone stimulus cytokinesis positive regulation of centrosome duplication regulation of stress fiber assembly regulation of cell motility positive regulation of endothelial cell migration protein phosphorylation negative regulation of bicellular tight junction assembly vascular endothelial growth factor receptor signaling pathway positive regulation of gene expression regulation of cell adhesion regulation of circadian rhythm Rho protein signal transduction regulation of focal adhesion assembly negative regulation of angiogenesis regulation of keratinocyte differentiation negative regulation of myosin-light-chain-phosphatase activity I-kappaB kinase/NF-kappaB signaling regulation of establishment of cell polarity cortical actin cytoskeleton organization regulation of establishment of endothelial barrier actin cytoskeleton organization protein localization to plasma membrane G protein-coupled receptor signaling pathway aortic valve morphogenesis positive regulation of cardiac muscle hypertrophy peptidyl-serine phosphorylation peptidyl-threonine phosphorylation positive regulation of cell migration positive regulation of connective tissue growth factor production positive regulation of MAPK cascade regulation of protein metabolic process positive regulation of stress fiber assembly negative regulation of biomineral tissue development response to transforming growth factor beta positive regulation of fibroblast growth factor production regulation of angiotensin-activated signaling pathway negative regulation of protein localization to lysosome positive regulation of amyloid-beta formation positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process positive regulation of protein localization to early endosome positive regulation of amyloid precursor protein catabolic process positive regulation of connective tissue replacement response to angiotensin response to ischemia negative regulation of gene expression regulation of nervous system process negative regulation of nitric oxide biosynthetic process mRNA destabilization blood vessel diameter maintenance regulation of cellular response to hypoxia cellular response to acetylcholine mitotic cytokinesis actomyosin structure organization embryonic morphogenesis regulation of cell junction assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9475 19878 Ensembl ENSG00000134318 ENSMUSG00000020580 UniProt O75116 P70336 RefSeq (mRNA) NM_004850 NM_001321643 NM_009072 RefSeq (protein) NP_001308572 NP_004841 NP_033098 Location (UCSC) Chr 2: 11.18 – 11.35 Mb Chr 12: 16.89 – 16.99 Mb PubMed search
Wikidata
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Rho associated coiled-coil containing protein kinase 2 is a protein that in humans is encoded by the ROCK2 gene. Fasudil is an inhibitor of ROCK protein.

Function

The protein encoded by this gene is a serine/threonine kinase that regulates cytokinesis, smooth muscle contraction, the formation of actin stress fibers and focal adhesions, and the activation of the c-fos serum response element. This protein, which is an isozyme of ROCK1 is a target for the small GTPase Rho.

Further reading

• Trauger JW, Lin FF, Turner MS, Stephens J, LoGrasso PV (2002). "Kinetic mechanism for human Rho-Kinase II (ROCK-II)". Biochemistry. 41 (28): 8948–53. doi:10.1021/bi0258243. PMID 12102637.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

External links

• Overview of all the structural information available in the PDB for UniProt: O75116 (Human Rho-associated protein kinase 2 (ROCK2)) at the PDBe-KB.