// Workers AI · dad joke modeWhat did RNF168 say to its date? You're a ubiquitin match.
Ring finger protein 168 is a protein that in humans is encoded by the RNF168 gene.[5]
This gene encodes an E3 ubiquitin ligase protein that contains a RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-DNA and protein-protein interactions. The protein is involved in double-strand breaks (DSB) repair. Mutations in this gene result in RIDDLE syndrome.[6]
References
[edit]- 1 2 3 GRCh38: Ensembl release 89: ENSG00000163961 – Ensembl, May 2017
- 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000014074 – Ensembl, May 2017
- ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ Xie T, Qin H, Yuan Z, Zhang Y, Li X, Zheng L (February 2023). "Emerging Roles of RNF168 in Tumor Progression". Molecules. 28 (3). Basel, Switzerland: 1417. doi:10.3390/molecules28031417. PMC 9920519. PMID 36771081.
- ↑ "RNF168". Reference Sequence Collection; National Center for Biotechnology Information (NCBI). U.S. National Library of Medicine (NLM).
Further reading
[edit]- Kelliher J, Ghosal G, Leung JW (May 2022). "New answers to the old RIDDLE: RNF168 and the DNA damage response pathway". The FEBS Journal. 289 (9): 2467–2480. doi:10.1111/febs.15857. PMC 8486888. PMID 33797206.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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