// Workers AI · dad joke modeWhat did RNF123 say to its friend? "You're a factor in my life.

RNF123
Identifiers
Aliases	RNF123, KPC1, FP1477, ring finger protein 123
External IDs	OMIM: 614472; MGI: 2148796; HomoloGene: 11112; GeneCards: RNF123; OMA:RNF123 - orthologs
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2MA6
Enzyme activity EC # BRENDA ExPASy KEGG MetaCyc 2.3.2.27 ↗ ↗ ↗ ↗
Gene location (Human) Chr. Chromosome 3 (human) Band 3p21.31 Start 49,689,538 bp End 49,721,529 bp
Gene location (Mouse) Chr. Chromosome 9 (mouse) Band 9|9 F1 Start 107,928,733 bp End 107,960,545 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in muscle of thigh gastrocnemius muscle vastus lateralis muscle Skeletal muscle tissue of rectus abdominis right lobe of liver triceps brachii muscle body of tongue biceps brachii Skeletal muscle tissue of biceps brachii thoracic diaphragm Top expressed in neural layer of retina saccule otic vesicle muscle of thigh fetal liver hematopoietic progenitor cell lens otic placode cerebellar cortex skeletal muscle tissue triceps brachii muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function metal ion binding transferase activity ubiquitin-protein transferase activity Cellular component cytoplasm cytosol nuclear membrane Biological process protein ubiquitination protein deubiquitination proteolysis involved in cellular protein catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 63891 84585 Ensembl ENSG00000164068 ENSMUSG00000041528 UniProt Q5XPI4 Q5XPI3 RefSeq (mRNA) NM_022064 NM_032543 NM_001311152 RefSeq (protein) NP_071347 NP_001298081 NP_115932 Location (UCSC) Chr 3: 49.69 – 49.72 Mb Chr 9: 107.93 – 107.96 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

E3 ubiquitin-protein ligase RNF123 is an enzyme that in humans is encoded by the RNF123 gene.

The protein encoded by this gene contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. Increased expression of the gene has been associated with laminopathies, and in degradation of chromatin associated proteins such as HP1 (Chaturvedi et al, 2012, PMID: 23077635).

See also

• RING finger domain

Further reading

• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Wan D, Gong Y, Qin W, et al. (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. Bibcode:2004PNAS..10115724W. doi:10.1073/pnas.0404089101. PMC 524842. PMID 15498874.
• Kamura T, Hara T, Matsumoto M, et al. (2005). "Cytoplasmic ubiquitin ligase KPC regulates proteolysis of p27(Kip1) at G1 phase". Nat. Cell Biol. 6 (12): 1229–35. doi:10.1038/ncb1194. PMID 15531880. S2CID 12225217.
• Kotoshiba S, Kamura T, Hara T, et al. (2005). "Molecular dissection of the interaction between p27 and Kip1 ubiquitylation-promoting complex, the ubiquitin ligase that regulates proteolysis of p27 in G1 phase". J. Biol. Chem. 280 (18): 17694–700. doi:10.1074/jbc.M500866200. PMID 15746103.
• Hara T, Kamura T, Kotoshiba S, et al. (2005). "Role of the UBL-UBA protein KPC2 in degradation of p27 at G1 phase of the cell cycle". Mol. Cell. Biol. 25 (21): 9292–303. doi:10.1128/MCB.25.21.9292-9303.2005. PMC 1265808. PMID 16227581.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

External links

• RNF123+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)