RNF10

RNF10
Identifiers
Aliases	RNF10, RIE2, ring finger protein 10
External IDs	OMIM: 615998; MGI: 1859162; HomoloGene: 40990; GeneCards: RNF10; OMA:RNF10 - orthologs
Enzyme activity EC # BRENDA ExPASy KEGG MetaCyc 2.3.2.27 ↗ ↗ ↗ ↗
Gene location (Human) Chr. Chromosome 12 (human) Band 12q24.31 Start 120,533,480 bp End 120,577,588 bp
Gene location (Mouse) Chr. Chromosome 5 (mouse) Band 5 F|5 56.01 cM Start 115,379,471 bp End 115,410,957 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left testis right testis muscle of thigh gastrocnemius muscle sural nerve stromal cell of endometrium anterior pituitary ventricular zone epithelium of colon blood Top expressed in blood neural layer of retina entorhinal cortex choroid plexus of fourth ventricle lactiferous gland perirhinal cortex CA3 field muscle of thigh superior surface of tongue dentate gyrus of hippocampal formation granule cell More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding protein binding metal ion binding ubiquitin-protein transferase activity Cellular component cytoplasm nucleus Biological process positive regulation of transcription, DNA-templated positive regulation of myelination regulation of transcription, DNA-templated transcription, DNA-templated negative regulation of Schwann cell proliferation positive regulation of transcription by RNA polymerase II protein autoubiquitination Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9921 50849 Ensembl ENSG00000022840 ENSMUSG00000041740 UniProt Q8N5U6 Q3UIW5 RefSeq (mRNA) NM_014868 NM_001330474 NM_016698 NM_001302448 NM_001302449 RefSeq (protein) NP_001317403 NP_055683 NP_001289377 NP_001289378 NP_057907 Location (UCSC) Chr 12: 120.53 – 120.58 Mb Chr 5: 115.38 – 115.41 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

RING finger protein 10 is a protein that in humans is encoded by the RNF10 gene.

Function

The protein encoded by this gene contains a ring finger motif, which is known to be involved in protein-protein interactions. The specific function of this protein has not yet been determined. EST data suggests the existence of multiple alternatively spliced transcript variants, however, their full length nature is not known.

Further reading

• Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T (Jun 2002). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Research. 9 (3): 99–106. CiteSeerX 10.1.1.500.923. doi:10.1093/dnares/9.3.99. PMID 12168954.
• Nagase T, Seki N, Ishikawa K, Ohira M, Kawarabayasi Y, Ohara O, Tanaka A, Kotani H, Miyajima N, Nomura N (Oct 1996). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain". DNA Research. 3 (5): 321–9, 341–54. doi:10.1093/dnares/3.5.321. PMID 9039502.
• Seki N, Hattori A, Sugano S, Muramatsu M, Saito T (2000). "cDNA cloning, expression profile, and genomic structure of human and mouse RNF10/Rnf 10 genes, encoding a novel RING finger protein". Journal of Human Genetics. 45 (1): 38–42. doi:10.1007/s100380050007. PMID 10697961.
• Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (Sep 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.
• Lin J, Friesen MT, Bocangel P, Cheung D, Rawszer K, Wigle JT (Jul 2005). "Characterization of Mesenchyme Homeobox 2 (MEOX2) transcription factor binding to RING finger protein 10". Molecular and Cellular Biochemistry. 275 (1–2): 75–84. doi:10.1007/s11010-005-0823-3. PMID 16335786. S2CID 30515981.
• Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (Jan 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.