// Workers AI · dad joke modeWhat did RIOX2 say to its date? "You're ox-ceptable

RIOX2
Identifiers
Aliases	RIOX2, MDIG, MINA53, NO52, ROX, MINA, MYC-induced nuclear antigen, MYC induced nuclear antigen, ribosomal oxygenase 2, JMJD10
External IDs	OMIM: 612049; MGI: 1914264; GeneCards: RIOX2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2XDV, 4BU2, 4BXF
Enzyme activity
Gene location (Human)
Chr.	Chromosome 3 (human)
End	97,972,457 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	59,312,824 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; right lobe of thyroid gland; ; left lobe of thyroid gland; ; oral cavity; ; buccal mucosa cell; ; internal globus pallidus; ; parotid gland; ; body of pancreas; ; tendon of biceps brachii; ; Skeletal muscle tissue of rectus abdominis;
	Top expressed in
	otic placode; ; saccule; ; otic vesicle; ; primitive streak; ; epiblast; ; sternocleidomastoid muscle; ; temporal muscle; ; digastric muscle; ; embryo; ; right kidney;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	oxidoreductase activity; dioxygenase activity; metal ion binding; histone demethylase activity; identical protein binding; histone H3-methyl-lysine-4 demethylase activity; histone H3-methyl-lysine-36 demethylase activity; transcription corepressor activity;
Cellular component	nucleolus; transcription regulator complex; nucleus; nucleoplasm; cytosol;
Biological process	regulation of transcription, DNA-templated; negative regulation of transcription by RNA polymerase II; transcription, DNA-templated; negative regulation of transcription, DNA-templated; histone demethylation; chromatin remodeling; peptidyl-arginine hydroxylation; histone H3-K4 demethylation; ribosome biogenesis; histone H3-K36 demethylation; negative regulation of nucleic acid-templated transcription;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	84864
	67014
	ENSG00000170854
	ENSMUSG00000022724
	Q8IUF8
	Q8CD15
	NM_001042533; NM_001261829; NM_032778; NM_153182
	NM_025910
	NP_001035998; NP_001248758; NP_116167; NP_694822
	NP_080186
	Wikidata
View/Edit Human	View/Edit Mouse

Ribosomal oxygenase 2 is a protein that in humans is encoded by the RIOX2 gene.^[5]^[6]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000170854 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000022724 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Tsuneoka M, Koda Y, Soejima M, Teye K, Kimura H (Sep 2002). "A novel myc target gene, mina53, that is involved in cell proliferation". J Biol Chem. 277 (38): 35450–9. doi:10.1074/jbc.M204458200. PMID 12091391.
↑ "Entrez Gene: MINA MYC induced nuclear antigen".

Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Teye K, Tsuneoka M, Arima N, et al. (2004). "Increased Expression of a Myc Target Gene Mina53 in Human Colon Cancer". Am. J. Pathol. 164 (1): 205–16. doi:10.1016/S0002-9440(10)63111-2. PMC 1602225. PMID 14695334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Eilbracht J, Reichenzeller M, Hergt M, et al. (2004). "NO66, a Highly Conserved Dual Location Protein in the Nucleolus and in a Special Type of Synchronously Replicating Chromatin". Mol. Biol. Cell. 15 (4): 1816–32. doi:10.1091/mbc.E03-08-0623. PMC 379278. PMID 14742713.
Tsuneoka M, Fujita H, Arima N, et al. (2005). "Mina53 as a potential prognostic factor for esophageal squamous cell carcinoma". Clin. Cancer Res. 10 (21): 7347–56. doi:10.1158/1078-0432.CCR-03-0543. PMID 15534111.
Eilbracht J, Kneissel S, Hofmann A, Schmidt-Zachmann MS (2005). "Protein NO52--a constitutive nucleolar component sharing high sequence homologies to protein NO66". Eur. J. Cell Biol. 84 (2–3): 279–94. doi:10.1016/j.ejcb.2004.12.022. PMID 15819408.
Zhang Y, Lu Y, Yuan BZ, et al. (2005). "The Human mineral dust-induced gene, mdig, is a cell growth regulating gene associated with lung cancer". Oncogene. 24 (31): 4873–82. doi:10.1038/sj.onc.1208668. PMID 15897898. S2CID 24239327.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Teye K, Arima N, Nakamura Y, et al. (2007). "Expression of Myc target gene mina53 in subtypes of human lymphoma". Oncol. Rep. 18 (4): 841–8. doi:10.3892/or.18.4.841. PMID 17786344.
Ishizaki H, Yano H, Tsuneoka M, et al. (2007). "Overexpression of the myc target gene Mina53 in advanced renal cell carcinoma". Pathol. Int. 57 (10): 672–80. doi:10.1111/j.1440-1827.2007.02156.x. PMID 17803656. S2CID 20991987.

This article on a gene on human chromosome 3 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000170854 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000022724 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12091391-5] Tsuneoka M, Koda Y, Soejima M, Teye K, Kimura H (Sep 2002). "A novel myc target gene, mina53, that is involved in cell proliferation". J Biol Chem. 277 (38): 35450–9. doi:10.1074/jbc.M204458200. PMID 12091391.

[entrez-6] "Entrez Gene: MINA MYC induced nuclear antigen".

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// Workers AI · dad joke modeWhat did RIOX2 say to its date? "You're ox-ceptable

References

Further reading