RINT1

RINT1
Identifiers
Aliases	RINT1, RINT-1, RAD50 interactor 1, ILFS3
External IDs	OMIM: 610089; MGI: 1916233; GeneCards: RINT1
Gene location (Human)
Chr.	Chromosome 7 (human)
End	105,567,677 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	24,025,367 bp
RNA expression pattern
	Top expressed in
	tibia; ; testicle; ; body of pancreas; ; muscle of thigh; ; gastrocnemius muscle; ; right uterine tube; ; Achilles tendon; ; skin of abdomen; ; skin of leg; ; cerebellar hemisphere;
	Top expressed in
	Rostral migratory stream; ; spermatocyte; ; tail of embryo; ; islet of Langerhans; ; fossa; ; right kidney; ; esophagus; ; genital tubercle; ; stomach; ; neural tube;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding;
Cellular component	cytoplasm; Dsl1/NZR complex; endoplasmic reticulum membrane; endoplasmic reticulum; membrane; cytosol;
Biological process	protein transport; cell cycle; regulation of ER to Golgi vesicle-mediated transport; Golgi vesicle transport; vesicle-mediated transport; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum; Golgi organization;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	60561
	72772
	ENSG00000135249
	ENSMUSG00000028999
	Q6NUQ1
	Q8BZ36
	NM_021930; NM_001346599; NM_001346600; NM_001346601; NM_001346603
	NM_177323; NM_001310467
	NP_001333528; NP_001333529; NP_001333530; NP_001333532; NP_068749
	NP_001297396; NP_796297
	Wikidata
View/Edit Human	View/Edit Mouse

RAD50-interacting protein 1 is a protein that in humans is encoded by the RINT1 gene.^[5]^[6]^[7]

Interactions

RINT1 has been shown to interact with Rad50^[5] and ZW10.^[6]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000135249 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028999 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 Xiao J, Liu CC, Chen PL, Lee WH (March 2001). "RINT-1, a novel Rad50-interacting protein, participates in radiation-induced G(2)/M checkpoint control". The Journal of Biological Chemistry. 276 (9): 6105–6111. doi:10.1074/jbc.M008893200. PMID 11096100.
1 2 Hirose H, Arasaki K, Dohmae N, Takio K, Hatsuzawa K, Nagahama M, et al. (March 2004). "Implication of ZW10 in membrane trafficking between the endoplasmic reticulum and Golgi". The EMBO Journal. 23 (6): 1267–1278. doi:10.1038/sj.emboj.7600135. PMC 381410. PMID 15029241.
↑ "Entrez Gene: RINT1 RAD50 interactor 1".

Sanger Centre T, Washington University Genome Sequencing Cente T (November 1998). "Toward a complete human genome sequence". Genome Research. 8 (11): 1097–1108. doi:10.1101/gr.8.11.1097. PMID 9847074.
Nakajima K, Hirose H, Taniguchi M, Kurashina H, Arasaki K, Nagahama M, et al. (August 2004). "Involvement of BNIP1 in apoptosis and endoplasmic reticulum membrane fusion". The EMBO Journal. 23 (16): 3216–3226. doi:10.1038/sj.emboj.7600333. PMC 514507. PMID 15272311.
Arasaki K, Taniguchi M, Tani K, Tagaya M (2006). "RINT-1 Regulates the Localization and Entry of ZW10 to the Syntaxin 18 Complex". Molecular Biology of the Cell. 17 (6): 2780–2788. doi:10.1091/mbc.E05-10-0973. PMC 1474792. PMID 16571679.
Kong LJ, Meloni AR, Nevins JR (2006). "The Rb-related p130 protein controls telomere lengthening through an interaction with a Rad50-interacting protein, RINT-1". Molecular Cell. 22 (1): 63–71. doi:10.1016/j.molcel.2006.02.016. PMID 16600870.
Lin X, Liu CC, Gao Q, Zhang X, Wu G, Lee WH (July 2007). "RINT-1 serves as a tumor suppressor and maintains Golgi dynamics and centrosome integrity for cell survival". Molecular and Cellular Biology. 27 (13): 4905–4916. doi:10.1128/MCB.02396-06. PMC 1951495. PMID 17470549.
Sun Y, Shestakova A, Hunt L, Sehgal S, Lupashin V, Storrie B (October 2007). "Rab6 regulates both ZW10/RINT-1 and conserved oligomeric Golgi complex-dependent Golgi trafficking and homeostasis". Molecular Biology of the Cell. 18 (10): 4129–4142. doi:10.1091/mbc.E07-01-0080. PMC 1995728. PMID 17699596.

This article on a gene on human chromosome 7 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000135249 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028999 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[Xiao_2001-5] 1 2 Xiao J, Liu CC, Chen PL, Lee WH (March 2001). "RINT-1, a novel Rad50-interacting protein, participates in radiation-induced G(2)/M checkpoint control". The Journal of Biological Chemistry. 276 (9): 6105–6111. doi:10.1074/jbc.M008893200. PMID 11096100.

[Hirose_2004-6] 1 2 Hirose H, Arasaki K, Dohmae N, Takio K, Hatsuzawa K, Nagahama M, et al. (March 2004). "Implication of ZW10 in membrane trafficking between the endoplasmic reticulum and Golgi". The EMBO Journal. 23 (6): 1267–1278. doi:10.1038/sj.emboj.7600135. PMC 381410. PMID 15029241.

[entrez-7] "Entrez Gene: RINT1 RAD50 interactor 1".

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RINT1

Interactions

References

Further reading